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Dextromethorphan 전처치는 정상성인의 구혈대 통증을 감소시키지 못한다.

Other Titles
 Dextromethorphan pretreatment does not reduce the tourniquet pain in normal volunteer. 
Authors
 정성량  ;  최윤  ;  임중우  ;  민홍기  ;  전희정  ;  박태성 
Citation
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.39(2) : 153-159, 2000 
Journal Title
Journal of Korean Society of Anesthesiologist(대한마취과학회지)
ISSN
 0302-5780 
Issue Date
2000
Keywords
Antagonist ; miscellaneous ; dextromethorphan ; Pain ; tourniquet
Abstract
BACKGROUND
Dextromethorphan (DEX) is an NMDA receptor antagonist which has recently been introduced for the treatment of chronic pain mainly to reduce the central sensitization component of pain. It is also reported to reduce the pain from acute ischemia of an extremity in a rat model which has a similar mechanism as tourniquet pain. The purpose of this experiment was to see if dextromethorphan could reduce tourniquet pain in normal volunteers.
METHODS
A double blind randomized cross-over test was done on ten healthy male volunteers. Each subject was orally administered with three different doses of DEX (placebo, 30, 60 mg) 1 h before the study according to a preallocated randomized table. The subject was not reallocated for the test within two weeks of the previous test. After a 10 minute acclimation period before each test, the degree of tourniquet pain measured by VAS, arterial blood pressure, heart rate, respiration rate, and pressure-evoked pain were measured before and every 5 minutes after inflation of the tourniquet until the subject felt unbearable pain. A mixed model for repeated measurement of data was used for statistical analysis (P < 0.05).
RESULTS
There was no statistical difference between different doses of DEX including the placebo. Rather, there was a tendency that DEX increases the pain. And there also was a tendency that average time to reach unbearable pain was decreased by DEX (P > 0.05).
CONCLUSIONS
DEX is not effective in controlling tourniquet pain in normal awake subjects.
Files in This Item:
T200003359.pdf Download
DOI
10.4097/kjae.2000.39.2.153
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Leem, Joong Woo(임중우) ORCID logo https://orcid.org/0000-0002-1605-2230
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172073
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