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개를 이용한 체외순환 모델에서 혈압의 변동이 주요 장기로의 혈류분포에 미치는 영향

Other Titles
 Role of perfusion pressure in major organ blood flow during cardiopulmonary bypass in canine 
 곽영란  ;  박영환  ;  남상범  ;  오영준  ;  김승호  ;  홍용우 
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.39(5) : 748-755, 2000 
Journal Title
Journal of Korean Society of Anesthesiologist(대한마취과학회지)
Issue Date
Heart ; cardiopulmonary bypass ; Measurement techniques ; blood flow ; Monitoring ; blood pressure
There has been no report about the effects of blood pressure (BP) on the change of blood flow (BF) to major organs when pump flow is maintained during cardiopulmonary bypass (CPB). We evaluated the changes of the BF and oxygen consumption of major organs when BP was controlled by vasopressors or vasodilators during CPB.
Carotid, femoral, hepatic and renal arteries and veins were exposed and arteries were cannulated for pressure monitoring, except the hepatic artery and arteries on the opposite side were exposed for the measurement of BF in 7 dogs. Temperature was lowered to 30oC after initiation of CPB and phenylephrine or sodium nitroprusside was infused to increase or decrease BP about 30% under the same pump flow. BP and BF were measured before CPB, before the infusion of drugs and when BP was changed by vasoactive drugs. Blood gas analyses were performed from the artery and each vein while the BF was measured.
The change of BP didn't affect carotid and renal BF. However, hepatic BF decreased about 50% when BP was reduced and femoral BF changed in the opposite way of BP change. Oxygen consumption of each organ wasn't influenced by BP. CONCLSIONS: When pump flow was constantly maintained, changes in BP redistributed BF to major organs but didn't affect oxygen consumption. The brain and kidney have the ability of autoregulation of BF unlike the liver or legs. Hepatic BF was dependent on perfusion pressure and a decrease in BP by vasodilators during CPB may be not good for the liver.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
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