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좌심실비대증이 동반된 환자의 개심술시 verapamil 심정지액이 심근기능 보존에 미치는 영향

Other Titles
 Effects of verapamil cardioplegia on the hypertrophied left ventricle undergoing cardiopulmonary bypass 
 박원선  ;  곽영란  ;  이춘수  ;  김진호  ;  강원철 
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.39(6) : 804-810, 2000 
Journal Title
Journal of Korean Society of Anesthesiologist(대한마취과학회지)
Issue Date
Heart ; myocardial protection ; ventricular hypertrophy ; verapamil cardioplegia ; Monitoring ; transesophageal echocardiography ; Surgery ; cardiac
Background : Verapamil, a calcium channel blocker, is known to protect the myocardium against ischemia and reperfusion injury. The hypertrophied myocardium is at greater risk for ischemic damage compared to the normal heart during cardiopulmonnry bypass (CPB). We evaluated the myocardial protective effect of verapamil cardioplegia on the hypertrophied left ventricle during CPB. Methods : Seventeen patients with end-diastolic anterior wall thickness (DAWT) greater than 11 mm in an M-mode echocardiogram were cansented to participate in this study. Patients were randomized to receive either standard hyperkalemic blood cardioplegic solution (n=8) or the same solution with verapamil (n=9). End systolic anterior wall thickeness (SAWT) and DAWT were measured by an M-mode echocardiogram and the left ventricular ejection fraction (LVEF) was calculated with a 2-dimension echocardiogram before and after CPB. Simultaneously, hemodynamic variables were measured. Results : There was no significant difference of DAWT and LVEF between both groups before and after CPB. DAWT was increased after CPB but this increase was attenuated by verapamil in patients with LVH. LVEF was decreased in both groups after CPB and the decrease in the verapamil group was not statistically significant but in the control group. Cardiac index and stroke volume index didn't show any significant differences between the two groups after CPB, either. Conclusions: DAWT increased which means myocardial edema was significant in patients with LVH; however, a verapamil cardioplegic solution decreased the amount of increase in DAWT. However, the verapamil cardioplegic solution didn't improve the hypertophied ventricular systolic function after CPB. (Korean J Anesthesiol 2000; 39: 804-810)
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
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