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Human immunodeficiency virus (HIV) 감염자에 있어서 3제 병용요법의 치료효과 및 안전성

Other Titles
 Antiviral effect and safety of triple combination therapy in human immunodeficiency virus (HIV)-infected persons 
 홍성관  ;  박윤수  ;  조정호  ;  노현정  ;  김효열  ;  장경희  ;  송영구  ;  김준명 
 Korean Journal of Medicine (대한내과학회지), Vol.58(5) : 582-589, 2000 
Journal Title
Korean Journal of Medicine(대한내과학회지)
Issue Date
Human immunodeficiency virus ; Antiretroviral treatment ; Zidovudine ; Protease inhibitor ; AIDS
Backg round : Antiretroviral combination therapy with one protease inhibitor and two reverse transcriptase inhibitors is profoundly suppressive of HIV replication. T o determine the efficacy and safety of the triple combination therapy in persons with HIV infection in Korea, we analyzed the response of therapy in terms of immunity and viral load.
Methods : Ten persons with HIV infection, who were treated with triple combination therapy at least 12 months at Yonsei University College of Medicine from 1997 to 1999 were studied. The triple combination therapy regimen consisted of two reverse transcriptase inhibitors (zidovudine or didanosine, lamivudine) and one protease inhibitor (indinavir ). We analyzed the levels of HIV RNA, CD4+ cell counts, β2MG, and p24Ag before and after treatment . Adverse drug reactions during therapy were described.
Result s : The mean age of patients at treatment was 38.7 years . Nine patients were male, and 1 patient was female. Six patients received triple combination therapy as initial treatment, while 4 patients received it as re- treatment . The mean level of HIV RNA was 129,222 copies/mm3 before treatment . RNA level decreased to less than 500 copies/mm3 (non- detectable range) at 1 month in 7 of 10 patients, at 12 months in 9 of 10 patients. The mean CD4+ cell counts was 206/mm3 before treatment, and 376/mm3 after 12 months treatment . The β2MG decreased to 2.7 mg/L from 2.8 mg/L after 12 months of treatment . The p24Ag was positive in 3 of 10 patients and negative in all of the patients at 3 months treatment . Mild hyperbilirubinemia (5 cases) was the most frequent adverse reaction followed by flank pain (3 cases), skin rash (2 cases ), abdominal discomfort (2 cases), and mild elevation of AST/ALT (1 case).
Conclusion : The triple combination therapy in HIV infection appeared to be generally well tolerated, and was able to profoundly sustain suppression of HIV replication.(Korean J Med 58:582- 589, 2000)
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
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