579 171

Cited 0 times in

결장암 환자에서 근치적 수술후 5- Fluorouracil과 leucovorin 보조 항암요법의 용량 및 용량 강도에 따른 효과

Other Titles
 Effect of 5-FU plus leucovorin for adjuvant chemotherapy according to dose related factors in colon cancer 
Authors
 심광용  ;  안중배  ;  정희철  ;  박준오  ;  유내춘  ;  라선영  ;  노재경  ;  김병수  ;  김남규  ;  민진식  ;  정현철 
Citation
 Korean Journal of Medicine (대한내과학회지), Vol.59(3) : 290-299, 2000 
Journal Title
Korean Journal of Medicine(대한내과학회지)
ISSN
 1226-329X 
Issue Date
2000
Keywords
Colonic neoplasms ; Chemotherapy ; Adjuvant ; Fluorouracil ; Dosage Forms
Abstract
Background : In patients with stage C colon cancer, surgery followed by adjuvant chemotherapy with 5- fluorouracil (5- FU)/ leucovorin (LV) is considered to be the standard treatment. However, the objects of adjuvant therapy and the duration of treatment are still matters of controversy. We investigated the effect of dose related factor(delivered total dose of 5- FU per body square meter, actual dose intensity and relative dose intensity) of the adjuvant 5- FU/ leucovorin regimen on survival in colon cancer.
Methods : Of the colon cancer patients with Duke' s B2 and C stage diseases treated with curative resection from December, 1990 to December, 1996, 139 patients treated with 5- FU/LV as an adjuvant chemotherapy were evaluated. The delivered total dose of 5- FU per body square meter,
actual dose intensity and relative dose intensity were obtained. The patients were divided into two groups according to the median value of each factor and the survival rates were compared. Results : The total dose of 5- FU administrated per body square meter had a significant effect on the 5- year disease free and overall survival in stage B2 and C colon cancer patients(B2; p=0.025, p=0.045, respectively, C; p=0.011, p=0.0002, respectively). But survival was not affected by the dose intensity. Multivariate analysis demonstrated that only the total dose of 5- FU administrated per body surface area affected the 5- year disease free and overall survival(p=0.0016, p=0.0007, respectively).
Conclus ion : It can be concluded that the total dose of 5- FU administered is more important than the DI in adjuvant chemotherapy of colon cancer and the total dose of 5- FU had a significant effect on the survival rate in colon cancer patients. To confirm the total dose effect of 5- FU on survival in this study, multi- institutional, prospective randomized studies should be carried out.(Korean J Med 59:290- 299, 2000)
Files in This Item:
T200001424.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172026
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links