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백서 구개의 외과적 결손부에 자가배양상피조직 이식 및 TGF-β3 투여가 상악골의 성장에 미치는 영향

Other Titles
 MAXILLARY GROWTH FOLLOWING CULTURED EPIDERMAL TISSUE GRAFT AND THE ADMINISTRATION OF TGF-β_3$ ON SURGICALLY CREATED PALATAL DEFECTS IN RAT 
Authors
 박정현  ;  최병호  ;  강정완  ;  육종인  ;  김진  ;  이충국 
Citation
 Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지), Vol.26(6) : 565-580, 2000 
Journal Title
 Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지) 
ISSN
 2234-7550 
Issue Date
2000
Keywords
Cleft palate ; Maxillary growth ; Cultured epidermis graft ; Transforming growth factor beta 3
Abstract
This study was designed to evaluate the influence of cultured epidermal tissue graft and the administration of transforming growth factor(TGF)-β_3$ on maxillary growth in surgically created palatal defects. A total of 155 rats were divided into 2 groups according to surgical timing : postnatal 2 weeks(n=95), 4 weeks(n=40) and control(unoperated) group(n=20). The postnatal 2-week surgical group was subdivided into 3 groups according to repair methods: conventional surgery(Von Langenbeck technique)group(n=23); cultured tissue graft group(n=25); and full thickness skin graft group(n=25). Additionally, recombinant human TGF-β_3$ was administered(30ng or 150ng) on collagen matrix in surgically created palatal defects during surgery(9 conventional surgeries, 9 cultured tissue grafts) in 2-week-old rats. The results showed that all types of surgical treatment decreased maxillary growth compared with the control(unoperated) group(p<0.0001). On the other hand, the tissue graft group, whether cultured tissue or grafted skin, contributed to increased maxillary growth(p<0.0001).And exogenous TGF-β_3$ might play a role in connective tissue proliferation and new bone generation during wound healing on palatal defects. Our results suggest that grafting cultured epidermis with collagen matrix decreases the scar tension on maxillary growth more than conventional palatal surgery does. Therefore, exogenous TGF-β_3$ may contribute to accelerate wound healing on palatal defects.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Yi, Choong Kook(이충국)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172009
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