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한국의 Amatoxins 중독증

Other Titles
 Amatoxins Poisonings in Korea. 
Authors
 안병민  ;  이동수  ;  이강문  ;  강상범  ;  양진모  ;  박영민  ;  이영석  ;  정규원  ;  선희식  ;  박두호  ;  노현주1  ;  강영모1  ;  이종명1  ;  허정욱2  ;  최성곤3  ;  김정호4  ;  이상인4  ;  최승옥5  ;  최홍엽6  ;  권오선6  ;  구창덕7  ;  석순자8  ;  김양섭8 
Citation
 Korean Journal of Hepatology (대한간학회지), Vol.6(3) : 340-350, 2000 
Journal Title
Korean Journal of Hepatology(대한간학회지)
ISSN
 1738-222X 
Issue Date
2000
Keywords
amatoxins ; mortality ; Amanita virosa ; A. subjunquillea
Abstract
Background/Aims : From the review of Korean literature most fatal mushroom poisonings have been due to amatoxins with high mortality. So far there have never been investigations on the amatoxins poisonings such as annual incidence, mortality, common causal species, and endemic areas. This study was carried out to develop some basic statistics as part of studies for an effective management of amatoxins intoxications .
Method:
For the year 1999 authors collected cases of mushroom poisonings which had been mainly gathered from hospitals nation- wide. All of the cases with suggestive amatoxins poisonings were screened by symptomatology and laboratory findings . The causal species of mushrooms were identified grossly and microscopically. Res ults : A total of 54 victims with mushroom poisonings were evaluated. The causal mushroom toxins were diagnosed or strongly sugges ted as amatoxins in 43 of 54 victims. Eleven of 54 victims did not conform to the category of amatoxins intoxication due to absent or minimal elevation of aminotrans ferase. Mean age of the victims was 44.3 ± 23.3 (range: 7- 78) with male predominance (1.2 : 1). The causal species were confirmed, or strongly suggested, as Amanita virosa in 25 victims, Amanita subjunquillea in 14, and unknown species in 4. Thirty- five out of a total of 43 were regarded as moderate to severe intoxication (AST or ALT > 1,000 IU/L) with 20% mortality. Most fatal victims showed marked thrombocytopenia (40,000 ± 1a9,000/mm3) compared to non- fatal victims (109,066 ± 42,245/mm3). A total of 88.4% of victims was developed in the Kangwon and Kyungpuk provinces. Both are wes t of the Taebaek Mountains (38/43). Conclus ions : Although the common causal species for amatoxins poisonings in Korea are different from European countries and North America, the mortality is similar to that of those areas. In order to further reduce the mortality, beds ide diagnostic methods us ing biological fluids and more effective therapy for liver failure should be established.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171984
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