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Homeostasis Model Assessment법을 이용한 인술린저항성 평가의 한계

Other Titles
 Limitation of Validity of Homeostasis Model Assessment as a Index of Insulin Resistance 
 차봉수  ;  허갑범  ;  윤용석  ;  박석원  ;  송영득  ;  박효경  ;  김오연  ;  안철우  ;  남재현  ;  남수현  ;  이종호  ;  임승길  ;  김경래  ;  이현철 
 Journal of Korean Diabetes Association (당뇨병), Vol.24(5) : 541-551, 2000 
Journal Title
 Journal of Korean Diabetes Association (당뇨병) 
Issue Date
Homeostasis model assessment (HOMA) ; Euglycemic clamp test ; Validity ; Insulin resistance
Background: Homeostasis model assessment of insulin resistance(HOMA) had been proposed as a simple and inexpensive alternative to other complex procedures measuring insulin resistance. We evaluated the validity of HOMAIR, comparing to total glucose disposal rate measured by euglycemic clamp test in 63 subjects with normal glucose tolerance, 21 with impaired glucose tolerance and 47 with type 2 DM. Methods: HOMAIR and HOMAβcell function (Homeostasis model assessment of βcell function) were calculated with formula described by Matthews (HOMAIR: fasting insulin (μU/mL) X fasting glucose (mmol/L) / 22.5, HOMAβcell function: 20 X fasting insulin (μU/mL)/(fasting glucose(mmol/L)- 3.5)). 2-hour euglycemic(5mmol/L) hyperinsulinemic (717pmol/L) clamp test were carried out. Results: The strong inverse correlation(r=-0.658, <0.001) was shown between log transformed HOMA and total glucose disposal rates. The agreement of two methodes in the categorization according to insulin resistance was moderate (weighed a =0.45). The magnitude of correlation coefficients were smaller in subjects with lower BMI (BMI < 23.7 kg/m2, r = -0441 vs BMI > 23.7 kg/m2, r = -0.693, p = 0.0183), lower HOMAβcell function (HOMAβcell function 57.2, r = -0.514 vs HOMAβcell function≥57.2, r = -0.773, p = 0.0091) and higher fasting glucose levels (fasting glucose < 102 mg/dL, r = -0.697 vs fasting glucose > 102 mg/dl, r = -0.59, p = 0.0735). The results of correlation analysis was not significant in diabetics with lower BMI. Conclusion: Limitation of validity of HOMAIR should be carefully considered in subjects with lower BMI and lower fasting insulin to glucose levels, such as lean type 2 diabetes with insulin secretory defects (J Kor Diabetes Asso 24:541 551, 2000).
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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