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LY303366의 임상검체에서 분리된 Candida spp., Cryptococcus neoformans 및 Aspergillus spp.에 대한 시험관내 항균력

Other Titles
 In Vitro Activities of LY303366 against Clinical Isolates of Candida spp., Cryptococcus neoformans and Aspergillus spp. 
 이경원  ;  용동은  ;  신희봉  ;  김영아  ;  장윤섭 
 Korean Journal of Infectious Diseases (감염), Vol.32(4) : 274-279, 2000 
Journal Title
Korean Journal of Infectious Diseases(감염)
Issue Date
Antifungal activity ; LY303366 ; C. albicans ; C. neoformans ; Aspergillus spp.
Background : Fungal infection became more prevalent with the increase of compromised patients, requiring less toxic potent antifungal agents. LY303366, a new semisynthetic antifungal agent of echinocandin class, was reported to be active against Candida spp. and filamentous fungi.
Methods : In vitro activities of LY303366 were determined against clinical isolates of fungi by NCCLS broth microdilution test using RPMI 1640 medium.
Results : MIC90s of LY303366 were 0.03 μg/mL for C. albicans, 2 μg/mL for C. parapsilosis, 0.12 μg/mL for C. tropicalis. LY303366 was more active against C. albicans and C. tropicalis than amphotericin B, 5-fluorocytosine, or fluconazole. It was less active than other agents against C. neoformans. MIC range of LY303366 against Aspergillus spp. was 8->16 μg/mL.
Conclusion : Very high in vitro activity of LY-303366 against recent clinical isolates of Candida spp. including fluconazole resistant ones, suggests its usefulness for the treatment of candidal infections. (Korean J Infect Dis 32:274∼279, 2000)
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
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