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A bone replaceable artificial bone substitute : Morphological and physicochemical characterizations

DC Field Value Language
dc.contributor.author박종철-
dc.date.accessioned2019-11-11T05:30:24Z-
dc.date.available2019-11-11T05:30:24Z-
dc.date.issued2000-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171932-
dc.description.abstractA composite material consisting of carbonate apatite (CAp) and type I atelocollagen (AtCol) (88/12 in wt/wt%) was designed for use as an artificial bone substitute. CAp was synthesized at 58 degrees C by a solution-precipitation method and then heated at either 980 degrees C or 1,200 degrees C. In this study, type I AtCol was purified from bovine tail skins. A CAp-AtCol mixture was prepared by centirfugation and condensed into composite rods or disks. The scanning electron-microscopic (SEM) characterization indicated that the CAp synthesized at 58 degrees C displayed a crystallinity similar to that of natural bone and had a high porosity (mean pore size: about 3-10 microns in diameter). SEM also revealed that the CAp heated at 980 degrees C was more porous than that sintered at 1,200 degrees C, and the 1,200 degrees C-heated particles were more uniformly encapsulated by the AtCol fibers than the 980 degrees C-heated ones. A Fourier transformed-infrared spectroscopic analysis showed that the bands characteristic of carbonate ions were clearly observed in the 58 degrees C-synthesized CAp. To enhance the intramolecular cross-linking between the collagen molecules, CAp-AtCol composites were irradiated by ultraviolet (UV) ray (wave length 254 nm) for 4 hours or vacuum-dried at 150 degrees C for 2 hours. Compared to the non cross-linked composites, the UV-irradiated or dehydrothermally cross-linked composites showed significantly (p < 0.05) low collagen degradation and swelling ratio. Preliminary mechanical data demonstrated that the compressive strengths of the CAp-AtCol composites were higher than the values reported for bone.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHApatites*/chemistry-
dc.subject.MESHBone Substitutes*/chemistry-
dc.subject.MESHBone Transplantation-
dc.subject.MESHCattle-
dc.subject.MESHCollagen*/chemistry-
dc.titleA bone replaceable artificial bone substitute : Morphological and physicochemical characterizations-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학교실)-
dc.contributor.googleauthorJong-Chul Park-
dc.contributor.googleauthorDong-Wook Han-
dc.contributor.googleauthorHwal Suh-
dc.identifier.doi10.3349/ymj.2000.41.4.468-
dc.contributor.localIdA01662-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid10992808-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.affiliatedAuthor박종철-
dc.citation.volume41-
dc.citation.number4-
dc.citation.startPage468-
dc.citation.endPage476-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.41(4) : 468-476, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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