Cited 10 times in
A bone replaceable artificial bone substitute : Morphological and physicochemical characterizations
DC Field | Value | Language |
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dc.contributor.author | 박종철 | - |
dc.date.accessioned | 2019-11-11T05:30:24Z | - |
dc.date.available | 2019-11-11T05:30:24Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171932 | - |
dc.description.abstract | A composite material consisting of carbonate apatite (CAp) and type I atelocollagen (AtCol) (88/12 in wt/wt%) was designed for use as an artificial bone substitute. CAp was synthesized at 58 degrees C by a solution-precipitation method and then heated at either 980 degrees C or 1,200 degrees C. In this study, type I AtCol was purified from bovine tail skins. A CAp-AtCol mixture was prepared by centirfugation and condensed into composite rods or disks. The scanning electron-microscopic (SEM) characterization indicated that the CAp synthesized at 58 degrees C displayed a crystallinity similar to that of natural bone and had a high porosity (mean pore size: about 3-10 microns in diameter). SEM also revealed that the CAp heated at 980 degrees C was more porous than that sintered at 1,200 degrees C, and the 1,200 degrees C-heated particles were more uniformly encapsulated by the AtCol fibers than the 980 degrees C-heated ones. A Fourier transformed-infrared spectroscopic analysis showed that the bands characteristic of carbonate ions were clearly observed in the 58 degrees C-synthesized CAp. To enhance the intramolecular cross-linking between the collagen molecules, CAp-AtCol composites were irradiated by ultraviolet (UV) ray (wave length 254 nm) for 4 hours or vacuum-dried at 150 degrees C for 2 hours. Compared to the non cross-linked composites, the UV-irradiated or dehydrothermally cross-linked composites showed significantly (p < 0.05) low collagen degradation and swelling ratio. Preliminary mechanical data demonstrated that the compressive strengths of the CAp-AtCol composites were higher than the values reported for bone. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | Yonsei Medical Journal | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apatites*/chemistry | - |
dc.subject.MESH | Bone Substitutes*/chemistry | - |
dc.subject.MESH | Bone Transplantation | - |
dc.subject.MESH | Cattle | - |
dc.subject.MESH | Collagen*/chemistry | - |
dc.title | A bone replaceable artificial bone substitute : Morphological and physicochemical characterizations | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.contributor.googleauthor | Dong-Wook Han | - |
dc.contributor.googleauthor | Hwal Suh | - |
dc.identifier.doi | 10.3349/ymj.2000.41.4.468 | - |
dc.contributor.localId | A01662 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 10992808 | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | 박종철 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 468 | - |
dc.citation.endPage | 476 | - |
dc.identifier.bibliographicCitation | Yonsei Medical Journal, Vol.41(4) : 468-476, 2000 | - |
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