71 146

Cited 63 times in

Transplantation of neural stem cells: cellular & gene therapy for hypoxic-ischemic brain injury.

Authors
 Kook In Park 
Citation
 Yonsei Medical Journal, Vol.41(6) : 825-835, 2000 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2000
MeSH
Animals ; Brain/pathology ; Brain Diseases/pathology ; Brain Diseases/therapy* ; Brain Ischemia/pathology ; Brain Ischemia/therapy* ; Cell- and Tissue-Based Therapy* ; Genetic Therapy* ; Humans ; Nerve Tissue/cytology* ; Stem Cell Transplantation*
Keywords
Neural progenitors ; neural stem cells ; hypoxic-ischemic brain injury ; transplantation ; stroke ; migration ; differentiation ; neurons ; glia
Abstract
We have tracked the response of host and transplanted neural progenitors or stem cells to hypoxic-ischemic (HI) brain injury, and explored the therapeutic potential of neural stem cells (NSCs) injected into mice brains subjected to focal HI injury. Such cells may integrace appropriately into the degenerating central nervous system (CNS), and showed robust engraftment and foreign gene expression within the region of HI inury. They appeared to have migrated preferentially to the site of ischemia, experienced limited proliferation, and differentiated into neural cells lost to injury, trying to repopulate the damaged brain area. The transplantation of exogenous NSCs may, in fact, augment a natural self-repair process in which the damaged CNS "attempts" to mobilize its own pool of stem cells. Providing additional NSCs and trophic factors may optimize this response. Therefore, NSCs may provide a novel approach to reconstituting brains damaged by HI brain injury. Preliminary data in animal models of stroke lends support to these hypotheses.
Files in This Item:
T200002004.pdf Download
DOI
10.3349/ymj.2000.41.6.825
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171896
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links