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Amanita virosa induced toxic hepatitis: report of three cases

Authors
 Jae Gyun Lim  ;  Jeong-Ho Kim  ;  Chang Youl Lee  ;  Sang In Lee  ;  Yang Sup Kim 
Citation
 Yonsei Medical Journal, Vol.41(3) : 416-421, 2000 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2000
MeSH
Adult ; Amanita* ; Amanitins/poisoning* ; Chemical and Drug Induced Liver Injury/etiology* ; Chemical and Drug Induced Liver Injury/urine ; Female ; Humans ; Male ; Middle Aged ; Mushroom Poisoning/complications* ; Proteinuria/etiology
Keywords
Amanita virosa ; mushroom poisoning ; toxic hepatitis ; tubular proteinuria
Abstract
We report here three cases of Amanita virosa induced toxic hepatitis. Two of the three cases recovered but the other died 10 days after mushroom ingestion. Since the mortality of Amanita mushroom induced toxic hepatitis is very high, prompt diagnosis and aggressive therapeutic measures should be initiated as soon as possible. Our cases showed that the initial serum aminotransferase levels might not predict the clinical outcome of the patient, but that the prothrombin time (PT) seemed to be a more useful prognostic marker. Close monitoring of aminotransferase levels and PT as well as appropriate therapy are recommended. All three cases showed signs of proteinuria and we were able to characterize mixed tubular and glomerular type proteinuria at 3 or 4 days after ingestion in two cases. Among the previously reported Korean cases of suspected Amanita induced toxic hepatitis, most species could not be identified except for four cases of Amanita virosa. No cases of Amanita phalloides induced toxic hepatitis have been identified in Korea so far.
Files in This Item:
T200001636.pdf Download
DOI
10.3349/ymj.2000.41.3.416
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171892
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