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Odontogenic ghost cell carcinoma -A case report with reference to the relation between apoptosis and ghost cells.

 Jin Kim  ;  Eun H. Lee  ;  Jong I. Yook  ;  Jee Y. Han  ;  Jung H. Yoon  ;  Gary L. Ellis 
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology, Vol.90(5) : 630-635, 2000 
Journal Title
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology 
Issue Date
Adult ; Apoptosis* ; Cell Differentiation ; Cell Nucleus ; DNA, Neoplasm/analysis ; Humans ; Immunohistochemistry ; In Situ Nick-End Labeling ; Keratins/analysis ; Male ; Mandibular Neoplasms/classification ; Mandibular Neoplasms/pathology* ; Odontogenic Tumors/classification ; Odontogenic Tumors/pathology* ; Terminology as Topic
The neoplastic variant of calcifying odontogenic cyst has various designations, and its malignant counterpart has been reported as aggressive epithelial odontogenic ghost cell tumor or odontogenic ghost cell carcinoma. We present a case of odontogenic ghost cell carcinoma with reference to the relation between the ghost cells and apoptosis. A 33-year-old man complained of a mandibular mass. The mass occupied the entire right side of the mandible with destruction of both buccal and lingual bone. The mass also infiltrated into submandibular and sublingual spaces. Histologically, the mass was composed of a solid proliferation of hyperchromatic and pleomorphic epithelial cells with abnormal mitoses. Islands of ghost cells were frequently admixed with nucleated cells, and there were foci of ameloblastic differentiation. Immunohistochemical stains for cytokeratins, involucrin, and apoptosis-related proteins such as Bcl-2, Bcl-X(L), and Bax were done. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL) assay was also performed. The nucleated cells adjacent to the ghost cells expressed cytokeratins and involucrin, but the ghost cells had no reaction. Bcl-2 was negative. Both Bcl-X(L) and Bax were demonstrated in the nucleated cells adjacent to the ghost cells. The ghost cells exhibited Bax protein. Some nucleated cells adjacent to the ghost cells were positive with TUNEL assay. The above results indicate that ghost cells undergo abnormal terminal differentiation as an apoptotic process.
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2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
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