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Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft

Authors
 H Ikeda  ;  Y Tsuchida  ;  J Wu  ;  N Suzuki  ;  M Kuroiwa  ;  S H Choi  ;  A Morikawa 
Citation
 Oncology Reports, Vol.7(6) : 1265-1273, 2000 
Journal Title
ONCOLOGY REPORTS
ISSN
 1021-335X 
Issue Date
2000
MeSH
Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology* ; Antineoplastic Agents, Alkylating/administration & dosage ; Antineoplastic Agents, Alkylating/pharmacology* ; Antineoplastic Combined Chemotherapy Protocols/pharmacology* ; Busulfan/administration & dosage ; Busulfan/pharmacology* ; Dose-Response Relationship, Drug ; Humans ; Infant ; Injections, Intraperitoneal ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neuroblastoma/drug therapy* ; Nitrosourea Compounds/administration & dosage ; Nitrosourea Compounds/pharmacology* ; Organophosphorus Compounds/administration & dosage ; Organophosphorus Compounds/pharmacology* ; Xenograft Model Antitumor Assays
Abstract
We examined whether or not fotemustine, a new nitrosourea derivative, and busulfan, an agent already clinically used, are effective against human neuroblastoma, using a human neuroblastoma xenograft model designated TNB9. The maximum inhibition rate (MIR) of fotemustine against the TNB9 model was 44.6% with a total dose of fotemustine of 75 mg/kg, indicating that fotemustine is not effective against TNB9. The MIR of busulfan against the same model was 26.7% when a total dose of 135 mg/kg was administered orally to nude mice. Busulfan was also suspended in carboxy-methylcellulose, and was administered intraperitoneally. The MIRs were 19.4% and 36. 4% when busulfan was administered intraperitoneally at a total dose of 40 mg/kg and 60 mg/kg, respectively. The total doses of 40 mg/kg and 60 mg/kg did not show any adverse effects on mice, but were found to be ineffective against TNB9, indicating that busulfan might not be an effective chemotherapeutic agent against human neuroblastoma.
Full Text
https://www.spandidos-publications.com/or/7/6/1265
DOI
10.3892/or.7.6.1265
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Seung Hoon(최승훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171829
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