0 188

Cited 18 times in

Antiallodynic effects produced by stimulation of the periaqueductal gray matter in a rat model of neuropathic pain

Authors
 Bae Hwan Lee  ;  Se-Hun Park  ;  Ran Won  ;  Yong Gou Park  ;  Jin-Hun Sohn 
Citation
 Neuroscience Letters, Vol.291(1) : 29-32, 2000 
Journal Title
NEUROSCIENCE LETTERS
ISSN
 0304-3940 
Issue Date
2000
MeSH
Analgesia/methods* ; Animals ; Axotomy ; Cold Temperature ; Disease Models, Animal ; Electric Stimulation Therapy/methods* ; Electrodes, Implanted ; Hyperalgesia/etiology ; Male ; Naloxone/pharmacology ; Narcotic Antagonists/pharmacology ; Pain Measurement/drug effects ; Pain Threshold/drug effects ; Periaqueductal Gray/physiology* ; Physical Stimulation ; Rats ; Rats, Sprague-Dawley ; Sciatic Neuropathy/therapy* ; Sural Nerve/physiology ; Tibial Nerve/physiology
Keywords
Periaqueductal gray matter ; Neuropathic pain ; Analgesia ; Electrical stimulation ; Opioids ; Nerve injury
Abstract
It has been well documented that there is opioid resistance in neuropathic pain. This indicates that the endogenous opioid system may not be involved effectively in modulating neuropathic pain. The present study sought to determine if activation of the descending pain inhibition system might produce analgesia in the animal neuropathic model we developed. Under ketamine anesthesia, male Sprague-Dawley rats were chronically implanted with stimulating electrodes in the ventral periaqueductal gray matter (PAG) and both the tibial and sural nerves of the sciatic nerve branches were severed. Pain sensitivity was measured with a von Frey filament and acetone applied to the sensitive area for 1 week postoperatively. Rats with neuropathic pain syndrome after transection of the tibial and sural nerves were tested as to the analgesic effects of ventral PAG stimulation for an additional two weeks. Electrical stimulation of the ventral PAG turned out to be highly effective in alleviating neuropathic pain. Mechanical allodynia and cold allodynia were reduced by PAG stimulation. Naloxone reversed the antiallodynic effects of ventral PAG stimulation. These results suggest that activation of the descending pain inhibition system including the ventral PAG reduces neuropathic pain syndrome and that opiates are involved in this system.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304394000013756
DOI
10.1016/S0304-3940(00)01375-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Gou(박용구)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171821
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links