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Gating of store-operated channels by conformational coupling to ryanodine receptors

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dc.contributor.author신동민-
dc.date.accessioned2019-11-11T05:21:15Z-
dc.date.available2019-11-11T05:21:15Z-
dc.date.issued2000-
dc.identifier.issn1097-2765-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171804-
dc.description.abstractWe report here that RyRs interact with and gate the store-operated hTrp3 and Icrac channels. This gating contributes to activation of hTrp3 and Icrac by agonists. Coupling of hTrp3 to IP3Rs or RyRs in the same cells was found to be mutually exclusive. Biochemical and functional evidence suggest that mutually exclusive coupling reflects clustering and segregation of hTrp3-IP3R and hTrp3-RyR complexes in plasma membrane microdomains. Gating of CCE by RyRs indicates that gating by conformational coupling is not unique to skeletal muscle but is a general mechanism for communication between events in the plasma and endoplasmic reticulum membranes.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherCell Press-
dc.relation.isPartOfMolecular Cell-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBarium/pharmacokinetics-
dc.subject.MESHCaffeine/pharmacology-
dc.subject.MESHCalcium/metabolism-
dc.subject.MESHCalcium Channels/drug effects-
dc.subject.MESHCalcium Channels/physiology*-
dc.subject.MESHCalcium Signaling*-
dc.subject.MESHCarbachol/pharmacology-
dc.subject.MESHCell Line-
dc.subject.MESHCell Membrane/physiology-
dc.subject.MESHHeart/physiology-
dc.subject.MESHHumans-
dc.subject.MESHIon Channel Gating/drug effects-
dc.subject.MESHIon Channel Gating/physiology*-
dc.subject.MESHMuscle, Skeletal/physiology-
dc.subject.MESHPatch-Clamp Techniques-
dc.subject.MESHProtein Isoforms/physiology-
dc.subject.MESHRecombinant Proteins/drug effects-
dc.subject.MESHRecombinant Proteins/metabolism-
dc.subject.MESHRyanodine Receptor Calcium Release Channel/drug effects-
dc.subject.MESHRyanodine Receptor Calcium Release Channel/physiology*-
dc.subject.MESHTRPC Cation Channels-
dc.subject.MESHTransfection-
dc.titleGating of store-operated channels by conformational coupling to ryanodine receptors-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorKirill I. Kiselyov-
dc.contributor.googleauthorDong Min Shin-
dc.contributor.googleauthorYaming Wang-
dc.contributor.googleauthorIsaac N. Pessah-
dc.contributor.googleauthorPaul D. Allen-
dc.contributor.googleauthorShmuel Muallem-
dc.identifier.doi10.1016/S1097-2765(00)00041-1-
dc.contributor.localIdA02091-
dc.relation.journalcodeJ02256-
dc.identifier.eissn1097-4164-
dc.identifier.pmid10983988-
dc.contributor.alternativeNameShin, Dong Min-
dc.contributor.affiliatedAuthor신동민-
dc.citation.volume6-
dc.citation.number2-
dc.citation.startPage421-
dc.citation.endPage431-
dc.identifier.bibliographicCitationMolecular Cell, Vol.6(2) : 421-431, 2000-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
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