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Excretory-secretory product of Paragonimus westermani newly excysted metacercariae inhibits superoxide production of granulocytes stimulated with IgG.

Authors
 Myeong Heon Shin 
Citation
 Korean Journal of Parasitology, Vol.38(2) : 103-106, 2000 
Journal Title
 Korean Journal of Parasitology 
ISSN
 0023-4001 
Issue Date
2000
MeSH
Animals ; Granulocytes/immunology* ; Granulocytes/metabolism ; Helminth Proteins/metabolism ; Helminth Proteins/pharmacology* ; Humans ; Immunoglobulin G/immunology* ; Paragonimiasis/parasitology ; Paragonimus/growth & development ; Paragonimus/metabolism* ; Superoxides/metabolism*
Keywords
Paragonimus westermani ; excretory-secretory product (ESP) ; human IgG ; granulocytes ; superoxide
Abstract
It is well known that the cysteine proteases in excretory-secretory product (ESP) of Paragonimus westermani newly excysted metacercariae (PwNEM) are capable of degrading IgG in vitro. Recent evidence suggests that the IgG-coated surface, such as found on parasites, is one of the most effective physiologic stimuli for granulocyte activation. Therefore, this study was designed to investigate the effect of excretory-secretory product (ESP) of PwNEM on superoxide production of granulocytes stimulated with IgG. The 96-well plates were coated with human IgG (0, 10, 30, 100 micrograms/ml) in the absence or presence of ESP. When granulocytes were incubated in the wells coated with human IgG in the presence of ESP, the level of superoxide production of granulocytes was reduced to about 90% when compared to the cells incubated in the wells coated with IgG alone. This inhibitory effect of the ESP on IgG-induced superoxide production of granulocytes was concentration-dependent. These results suggest that ESP secreted by PwNEM may be important in the control of effector functions of granulocytes stimulated with IgG in human paragonimiasis.
Files in This Item:
T200002266.pdf Download
DOI
10.3347/kjp.2000.38.2.103
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Myeong Heon(신명헌) ORCID logo https://orcid.org/0000-0001-8207-6110
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171783
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