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혈장 섬유소원의 농도 및 섬유소원 유전자 다형성이 관동맥 질환의 발생에 미치는 영향

Other Titles
 The Effects of Plasma Fibrinogen and beta Fibrinogen Gene Polymorphisms on the Development of Coronary Artery Disease 
Authors
 박현영  ;  오수환  ;  권혁문  ;  김동수  ;  홍범기  ;  이남호  ;  장양수 
Citation
 Korean Circulation Journal, Vol.30(8) : 947-957, 2000 
Journal Title
 Korean Circulation Journal 
ISSN
 1738-5520 
Issue Date
2000
Keywords
Fibrinogen ; Coronary artery disease ; Genetics ; Polymorphism
Abstract
Background:Elevated plasma fibrinogen level has been shown to be an independent risk factor of ischemic heart disease, erebrovascular disease, and peripheral vascular disease. The aim of this study is to determine the associations of plasma fibrinogen levels, coronary artery disease (CAD), classical vascular risk factors, and genetic polymorphisms at position -455 and C448 of the β-fibrinogen gene. Methods:We measured the plasma fibrinogen levels and lipid levels in 374 patients with angiographically defined CAD and 290 control patients. The genotypes of β-fibrinogen in randomly selected patients were determined by restriction fragment length polymorphism and allele-specific oligomer hybridization. Results:1) Higher plasma fibrinogen levels were observed in the patients with CAD, especially who had multiple coronary artery atherosclerosis. 2) The plasma fibrinogen levels were higher in smokers, and positively related with age and total cholesterol levels. 3) The two polymorphisms were in tight linkage disequilibrium and the genotype frequencies were similar in patients and control subjects. The significant association between β-455G/A genotype and plasma fibrinogen was noted in females but not in males. 4) In logistic regression model, the elevated plasma fibrinogen was an independent risk factor of CAD. Conclusion:The present study shows that the plasma fibrinogen level is an independent risk factor for coronary atherosclerosis, and the genetic variants of the β fibrinogen gene are associated with an increased plasma fibrinogen in females. (Korean Circulation J 2000;30(8):947-957)
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171756
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