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The effect of long-term levodopa therapy on depression level in de novo patients with Parkinson's disease

Authors
 Chulhee Choi  ;  Young H. Sohn  ;  Joon H. Lee  ;  Jin-Soo Kim 
Citation
 Journal of the Neurological Sciences, Vol.172(1) : 12-16, 2000 
Journal Title
 Journal of the Neurological Sciences 
ISSN
 0022-510X 
Issue Date
2000
MeSH
Depressive Disorder/drug therapy* ; Depressive Disorder/psychology ; Female ; Humans ; Levodopa/administration & dosage* ; Male ; Middle Aged ; Parkinson Disease/drug therapy* ; Parkinson Disease/psychology ; Psychiatric Status Rating Scales ; Time Factors
Keywords
Parkinson’s disease ; Depression ; Dopamine ; Levodopa
Abstract
20) became non-depressed, while five patients (22%) among 23 initially non-depressed became depressed. With long-term levodopa therapy, the UPDRS-motor score significantly improved (35+/-15. 7-18+/-7.6), but the BDI score was unchanged (18+/-9.3-19+/-9.2). The initial BDI score was significantly and inversely correlated to the parkinsonian motor symptoms, but their percentage changes were not correlated to each other. These results provide strong support to previous observations that levodopa therapy does not alter parkinsonian depression as well as providing additional evidence to support the role of non-dopaminergic mechanisms in parkinsonian depression.
Full Text
https://www.sciencedirect.com/science/article/pii/S0022510X99001987
DOI
10.1016/S0022-510X(99)00198-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171746
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