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슬관절 골관절염 환자에 대한 Meloxicam의 유효성 및 안전성 평가를 위한 Diclofenac과의 공개 비교 무작위 다기관 임상 시험

Other Titles
 The Comparison of Clinical Efficacy and Safety of Meloxicam versus Diclofenac in Korean Patients with Osteoarthritis of the Knee; Open Multicenter Comparative Randomized Trial 
 송정식  ;  박용범  ;  이수곤  ;  안홍준  ;  이윤우  ;  이창근  ;  고재현  ;  고은미  ;  이은영  ;  이충기 
 Journal of the Korean Rheumatism Association (대한류마티스학회지), Vol.7(4) : 333-341, 2000 
Journal Title
 Journal of the Korean Rheumatism Association (대한류마티스학회지) 
Issue Date
Meloxicam ; Diclofenac ; Osteoarthritis
Objective: To assess the clinical efficacy and safety of meloxicam 7.5mg versus diclofenac 100mg slow release (SR) in the Korean patients with osteoarthritis of the knee. Methods: Ninety-one patients of four university hospitals in 1999 were randomized to receive once daily oral meloxicam 7.5mg (N=45) or diclofenac 100mg SR (N=46) for 8 weeks. Clinical efficacy was evaluated using 100mm Visual Analogue Scale (VAS) for pain, Lequesne index after 4, 8 weeks of treatment as well as the physician`s and patient`s global assessment at the end of treatment. Evaluations for clinical safety were performed using the incidence of adverse events, physical examinations, laboratory finding and total ingestion of antacid during the treatment. Results: After 8 weeks of therapy, both groups had significant improvement in 100mm VAS and Lequesne index than baseline although the difference between two groups did not reach statistical significance. The physician`s and patient`s global assessment were similar in two groups. The incidence of gastrointestinal adverse events was significantly lower in meloxicam group (24.4%) than diclofenac group (50.0%) (p<0.05). Conclusion: Meloxicam 7.5mg is comparable to diclofenac 100mg SR in the treatment of Korean patients with osteoarthritis of the knee. Furthermore meloxicam 7.5mg was well tolerated for 8 weeks and has safe advantage of a significantly lower incidence of gastrointestinal adverse events.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Lee, Soo Kon(이수곤)
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