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호산구증다증을 동반한 P - A N CA 양성 괴사성 사구체신염

Other Titles
 A case of p-ANCA Positive Necrotizing Glomerulonephritis with Eosinophilia 
 신장열  ;  강이화  ;  류동렬  ;  송정식  ;  이원기  ;  박용범  ;  김루시아  ;  정현주  ;  이수곤 
 Journal of the Korean Rheumatism Association (대한류마티스학회지), Vol.7(1) : 83-89, 2000 
Journal Title
 Journal of the Korean Rheumatism Association (대한류마티스학회지) 
Issue Date
ANCA ; Pauci-immune crescentic necrotizing glomerulonephritis ; Eosinophilia
Antineutrophil cytoplasmic antibodies (ANCAs) are now regarded as a serologic marker for pauci-immune crescentic necrotizing glomerulonephritis either in renal-limited form or in association with systemic vasculitis, such as Wegener’s granulomatosis, microscopic polyarteritis, and Churg-Strauss syndrome. Two major ANCA antigens have been indentified: proteinase3, which produces a cytoplasmic staining pattern termed C-ANCA, and myeloperoxidase, which produces a perinuclear pattern termed P-ANCA on ethanol-fixed neutrophils by indirect immunofluorescence. In ANCA- associated diseases, eosinphilia in excess of 1.5×1 09/L has been proposed to be characteristic of Churg-Strauss syndrome and is rare in other forms of ANCA-associated systemic vasculitis and crescentic necrotizing glomerulonephritis. Recently, there were two cases of P-ANCA positive crescentic necrotizing glomerulonephritis with peripheral blood eosinophilia and extrarenal microscopic vasculitis without asthma or granulomas. We experienced a patient with P-ANCA positive pauci-immune necrotizing glomerulonephritis with few eosinophilic infiltration and eosinophilia. He improved with oral prednisolone along with combination of intravenous cyclophosphamide. So we report this case with the review of literature.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Lee, Soo Kon(이수곤)
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