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Decreased trabecular bone mineral density in newly diagnosed inflammatory bowel disease patients in Korea

 Sang‐Ho Lee  ;  Hyo‐Jong Kim  ;  Suk‐Kyun Yang  ;  Won‐Ho Kim  ;  Yeong‐Shil Joo  ;  Seok‐Ho Dong  ;  Byung‐Ho Kim  ;  Jung‐Il Lee  ;  Young‐Woon Chang  ;  Rin Chang 
 Journal of Gastroenterology and Hepatology, Vol.15(5) : 512-518, 2000 
Journal Title
 Journal of Gastroenterology and Hepatology 
Issue Date
Absorptiometry, Photon ; Adolescent ; Adult ; Bone Density ; Bone Diseases, Metabolic/etiology* ; Female ; Humans ; Inflammatory Bowel Diseases/blood ; Inflammatory Bowel Diseases/complications* ; Inflammatory Bowel Diseases/physiopathology ; Korea ; Lumbar Vertebrae/diagnostic imaging ; Male ; Middle Aged ; Nutritional Status ; Prevalence ; Socioeconomic Factors
Asia ; bone mineral density ; Crohn’s disease ; inflammatory bowel disease ; osteopenia ; ulcerative colitis
BACKGROUND: Decreased bone mineral density (BMD) is common in Western patients with inflammatory bowel disease (IBD). However, BMD has never been studied in Asia where the demographic and socio-economic status are different from the West. The aim of this study was to investigate the prevalence and mechanisms of osteopenia in newly diagnosed Korean patients with IBD. METHODS: We studied 14 patients with Crohn's disease (CD) and 25 patients with ulcerative colitis (UC), all of whom had never been treated with corticosteroids. Bone mineral density was measured in the lumbar spine and the femoral neck by dual energy X-ray absorptiometry. Biochemical parameters including serum osteocalcin, parathyroid hormone, plasma inactive and active vitamin D, and urinary deoxypyridinoline were measured. RESULTS: The BMD Z score at the lumbar spine was lower both in CD and in UC patients, but there was no significant difference between the two groups. There was no significant difference in nutritional status or biochemical parameters of bone metabolism between patients with a normal BMD and those with a decreased BMD. CONCLUSIONS: Low BMD at the lumbar spine is common in newly diagnosed Korean patients with IBD, a result which is similar to Western studies. The mechanism for low bone mass remains undetermined; however, nutritional status and hormonal parameters of bone metabolism, and ethnic differences are not likely to be an important factor in the pathogenesis of this bone loss.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
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