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The effect of herpesvirus infection on the expression of cell adhesion molecules on cultured human dermal microvascular endothelial cells

Authors
 You Chan Kim  ;  Dongsik Bang  ;  Sungnack Lee  ;  Kwang-Hoon Lee 
Citation
 Journal of Dermatological Science, Vol.24(1) : 38-47, 2000 
Journal Title
 Journal of Dermatological Science 
ISSN
 0923-1811 
Issue Date
2000
MeSH
Cell Adhesion ; Cells, Cultured ; E-Selectin/biosynthesis* ; Endothelium, Vascular/metabolism* ; Endothelium, Vascular/pathology ; Endothelium, Vascular/virology* ; Herpes Simplex/metabolism* ; Herpes Simplex/pathology ; Humans ; Intercellular Adhesion Molecule-1/biosynthesis* ; Microcirculation ; Simplexvirus* ; Skin/blood supply ; T-Lymphocytes/pathology ; Vascular Cell Adhesion Molecule-1/biosynthesis*
Keywords
Herpesvirus ; ICAM-1 ; VCAM-1 ; E-selectin ; T-lymphocytes
Abstract
Cell-mediated immune response to herpes simplex virus (HSV) may be important in the pathogenesis of herpes keratitis, erythema multiforme or Behcet's disease. We examined whether herpesvirus infection regulates the expression of cell adhesion molecules on cultured human dermal microvascular endothelial cells (HDMEC) and the regulation of T-lymphocytes binding to HDMEC. The expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), or E-selectin on HDMEC increased significantly after treatment with HSV-1, HSV-2, or measles virus on HDMEC. Anti-IL-1 alpha antibody or anti-TNF alpha antibody partially inhibited the expression of ICAM-1, VCAM-1, or E-selectin on HDMEC. The binding of T-lymphocytes to HDMEC increased significantly after the treatment of HSV-1 or measles virus on HDMEC. The binding of T-lymphocytes to HDMEC was significantly inhibited after 16 h of incubation following treatment with anti-ICAM-1 antibody, anti-IL-1 alpha antibody or anti-TNF alpha antibody to HDMEC. These study results suggest that HSV induces the increased expression of ICAM-1, or induction of VCAM-1 and E-selectin on HDMEC and that among these adhesion molecules, the expression of ICAM-1 on HDMEC mainly regulates the binding of T-lymphocytes to HDMEC. The data also suggest that IL-1 alpha or TNF alpha which was produced by HSV infected HDMEC may be related to these events.
Full Text
https://www.sciencedirect.com/science/article/pii/S0923181100000803
DOI
10.1016/S0923-1811(00)00080-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Bang, Dong Sik(방동식)
Lee, Kwang Hoon(이광훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171696
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