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Chronic alcohol intake differently influences glucose metabolism according to nutritional status

Authors
 Bong Soo Cha  ;  Chul Woo Ahn  ;  Young Duk Song  ;  Sung Kil Lim  ;  Kyung Rae Kim  ;  Kap Bum Huh  ;  Hyun Chul Lee 
Citation
 Journal of Clinical Endocrinology & Metabolism, Vol.85(10) : 3646-3652, 2000 
Journal Title
 Journal of Clinical Endocrinology & Metabolism 
ISSN
 0021-972X 
Issue Date
2000
MeSH
Adipose Tissue/metabolism ; Alcohol Drinking/metabolism* ; Animals ; Diet ; Epididymis/metabolism ; Glucose/metabolism* ; Glucose Clamp Technique ; Glucose Tolerance Test ; Glycogen Synthase/metabolism ; Insulin/metabolism ; Male ; Muscle, Skeletal/metabolism ; Nutritional Status/drug effects* ; Organ Size/physiology ; Pancreas/drug effects ; Pancreas/metabolism ; Protein Deficiency/metabolism ; Rats ; Rats, Sprague-Dawley
Abstract
We investigated the potential different effects of a chronic alcohol intake on glucose metabolism according to nutritional status in growing rats. Eighty weanling 4-week-old male Sprague Dawley rats were fed with low (5%, wt/wt) or control (22%) protein diet for 8 weeks. Each group was subdivided into alcohol (5 g/kg(-1) x day(-1)) or saline gavage rats during the last 4 weeks. At 12 weeks of age, we measured the weights of the body, pancreas, and epididymal fat; glycogen synthase activity of gastrocnemius muscle; and insulin content of the pancreas. We performed an ip glucose tolerance test and a euglycemic hyperinsulinemic clamp test. Weight gain was almost arrested in protein-deficient rats. The relative weight and insulin content of the pancreas and glycogen synthase activity were not different among the four groups, but the relative amount of epididymal fat decreased only in protein-deficient saline rats. Insulin response after glucose challenge and glucose disposal rate during the euglycemic clamp were both markedly decreased in protein-deficient saline rats, but not changed in protein-deficient alcohol rats. Protein-deficiency per se causes deterioration both in insulin secretory function and in sensitivity, but these defects are protected by a chronic alcohol intake. In a protein-sufficient state, alcohol intake gives no additional effects on glucose metabolism. Therefore, according to individual nutritional status, the metabolic effect of alcohol intake appears differently.
Full Text
https://academic.oup.com/jcem/article/85/10/3646/2852648
DOI
10.1210/jcem.85.10.6905
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171685
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