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Exercise therapy effect on natural killer cell cytotoxic activity in stomach cancer patients after curative surgery

 Young-Moo Na  ;  Min-Young Kim  ;  Yong-Kyun Kim  ;  Young-Ran Ha  ;  Dong Sup Yoon 
 Archives of Physical Medicine and Rehabilitation, Vol.81(6) : 777-779, 2000 
Journal Title
 Archives of Physical Medicine and Rehabilitation 
Issue Date
Adult ; Aged ; Exercise Therapy* ; Humans ; Killer Cells, Natural/metabolism* ; Linear Models ; Lymphatic Metastasis ; Middle Aged ; Prospective Studies ; Stomach Neoplasms/immunology ; Stomach Neoplasms/surgery ; Stomach Neoplasms/therapy*
OBJECTIVE: To evaluate the effect of early exercise therapy on the natural killer cell cytotoxic activity (NKCA) of patients who had undergone curative resection of stomach cancer. DESIGN: Prospective study. PATIENTS: Thirty-five stomach cancer patients who had undergone curative surgery were randomly divided into an exercise group (n = 17) and a control group (n = 18). INTERVENTION: From postoperative day 2, moderated exercise using arm and bicycle ergometers performed twice a day, 5 times a week, for 14 days. The intensity of exercise was 60% of maximal heart rate. Venous blood samples were obtained on postoperative days 1, 7, and 14. MAIN OUTCOME MEASURE: Mean sequential change of NKCA. RESULTS: The mean sequential change of NKCA decreased until postoperative day 7 and then increased. Mean NKCA of day 7 decreased in both groups, compared with that at postoperative day 1. At day 14, the mean NKCA of the exercise group demonstrated a significant increase compared with that of the control group (p < .05). CONCLUSION: This study suggests that early moderate exercise has a beneficial effect on the function of in vitro NK cells in stomach cancer patients after curative surgery.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Dong Sup(윤동섭) ORCID logo https://orcid.org/0000-0001-6444-9606
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