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Expression of cyclin E and p27(KIP1) in cervical carcinoma

 Young Tae Kim  ;  Eun Kyoung Choi  ;  Nam Hoon Cho  ;  Jae Hung Ko  ;  Woo Ick Yang  ;  Jae Wook Kim  ;  Seung Ho Lee 
 Cancer Letters, Vol.153(1~2) : 41-50, 2000 
Journal Title
 Cancer Letters 
Issue Date
Adult ; Age Factors ; Aged ; Cell Cycle Proteins/analysis ; Cervical Intraepithelial Neoplasia/diagnosis ; Cervical Intraepithelial Neoplasia/metabolism* ; Cervical Intraepithelial Neoplasia/pathology ; Cervical Intraepithelial Neoplasia/virology ; Cyclin E/biosynthesis* ; Cyclin-Dependent Kinase Inhibitor p27 ; Female ; Humans ; Menopause ; Microtubule-Associated Proteins/biosynthesis* ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Papillomaviridae/isolation & purification ; Prognosis ; Tumor Suppressor Proteins* ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/metabolism* ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/virology
Cell-cycle regulators ; Cyclin E ; p27KIP1 ; Cervical carcinoma
Carcinogenesis is characterized by deregulation of the cell cycle. Although p53 is still the most important cell-cycle regulator in human malignancies, there is an increased body of evidence indicating that the aberrant expression of cyclins and cyclin-dependent kinase (CDK) inhibitors is considered as one of the most important events in malignant transformation of various human cancers. Among these cell-cycle regulators, the role of cyclin E and p27(KIP1) in the tumorigenesis of the uterine cervix has been poorly defined. Using formalin-fixed, paraffin-embedded cervical tissues, we investigated the expression of cyclin E and p27(KIP1) by immunohistochemistry, and human papillomavirus (HPV) types 16 and 18 by nested polymerase chain reaction (PCR) in 22 control cases, 23 cases with cervical intraepithelial neoplasia (CIN), and 45 patients with invasive cervical carcinoma (ICC). The p27 index (P27I) was significantly lower in patients with ICC and CIN compared to those with a normal cervix. Patients with either invasive cancer or CIN were found to have a significantly higher cyclin E index (CEI) than the controls (P<0.05). Our results were consistent with the concept that the deregulated expression of cyclin E and p27(KIP1) may play an important role in the neoplastic transformation of cervical carcinoma.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
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