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Transcriptional induction fo Nur77 by indomethacin that results in apoptosis of colon cancer cells

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dc.contributor.author김세종-
dc.date.accessioned2019-11-11T05:03:00Z-
dc.date.available2019-11-11T05:03:00Z-
dc.date.issued2000-
dc.identifier.issn0918-6158-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171571-
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) have cancer preventive and tumor regressive effects in the human colon, perhaps due to their capability to induce apoptosis of the colon cancer cells. Here, we report that indomethacin induced the expression of Nur77 which has been implicated in activation-induced apoptosis of T-lymphocytes, in a colon cancer cell line, HCT-15. The transcript- and protein-level, the transcriptional activity of Nur77 promoter, and the DNA binding of Nur77 were significantly induced following indomethacin treatment. Among the two potential trans-acting factors that activate Nur77-promoter, indomethacin induced DNA binding and reporter gene activity of AP-1, but not that of related serum response factor (RSRF), suggesting that the transcriptional induction of Nur77 may be mediated through activation of AP-I. Further, we showed that all trans-RA repressed the induction of Nur77 as well as the apoptosis-induced by indomethacin, providing evidence that transcriptional induction of Nur77 may be an important mechanism by which indomethacin induces apoptosis in colon cancer cells.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPharmaceutical Society of Japan-
dc.relation.isPartOfBiological & Pharmaceutical Bulletin-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/pharmacology-
dc.subject.MESHAntineoplastic Agents/pharmacology-
dc.subject.MESHApoptosis*-
dc.subject.MESHColonic Neoplasms/drug therapy-
dc.subject.MESHColonic Neoplasms/genetics-
dc.subject.MESHColonic Neoplasms/metabolism*-
dc.subject.MESHDNA-Binding Proteins/genetics*-
dc.subject.MESHDNA-Binding Proteins/physiology-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHumans-
dc.subject.MESHIndomethacin/antagonists & inhibitors-
dc.subject.MESHIndomethacin/pharmacology*-
dc.subject.MESHNuclear Proteins/physiology-
dc.subject.MESHNuclear Receptor Subfamily 4, Group A, Member 1-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHReceptors, Cytoplasmic and Nuclear-
dc.subject.MESHReceptors, Steroid-
dc.subject.MESHSerum Response Factor-
dc.subject.MESHTranscription Factor AP-1/physiology-
dc.subject.MESHTranscription Factors/genetics*-
dc.subject.MESHTranscriptional Activation/drug effects*-
dc.subject.MESHTretinoin/pharmacology-
dc.subject.MESHTumor Cells, Cultured-
dc.titleTranscriptional induction fo Nur77 by indomethacin that results in apoptosis of colon cancer cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학교실)-
dc.contributor.googleauthorHyo-Jin Kang-
dc.contributor.googleauthorMoon-Jung Song-
dc.contributor.googleauthorSe Young Choung-
dc.contributor.googleauthorSe Jong Kim-
dc.contributor.googleauthorMi-Ock Lee-
dc.contributor.localIdA00603-
dc.relation.journalcodeJ00300-
dc.identifier.eissn1347-5215-
dc.identifier.pmid10919358-
dc.subject.keywordNur77-
dc.subject.keywordindomethacin-
dc.subject.keywordcolon cancer-
dc.subject.keywordapoptosis-
dc.contributor.alternativeNameKim, Se Jong-
dc.contributor.affiliatedAuthor김세종-
dc.citation.volume23-
dc.citation.number7-
dc.citation.startPage815-
dc.citation.endPage819-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, Vol.23(7) : 815-819, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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