0 74

Cited 61 times in

The brain lesion responsible for parkinsonism after carbon monoxide poisoning

 Young H. Sohn  ;  Yong Jeong  ;  Hyun S. Kim  ;  Joo H. Im  ;  Jin-Soo Kim 
 Archives of Neurology, Vol.57(8) : 1214-1218, 2000 
Journal Title
 Archives of Neurology 
Issue Date
Aspartic Acid/analogs & derivatives ; Aspartic Acid/analysis ; Brain Chemistry ; Carbon Monoxide Poisoning/complications* ; Carrier Proteins/analysis ; Choline/analysis ; Cognition Disorders/diagnostic imaging ; Cognition Disorders/etiology ; Dopamine Plasma Membrane Transport Proteins ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Membrane Glycoproteins* ; Membrane Transport Proteins* ; Middle Aged ; Nerve Tissue Proteins* ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/etiology* ; Phosphocreatine/analysis ; Tomography, Emission-Computed, Single-Photon
BACKGROUND: Parkinsonism is a common neurological sequela of carbon monoxide (CO) poisoning, but its pathophysiological mechanism has yet to be clarified. OBJECTIVES: To describe a married couple who were both affected by CO poisoning, but only 1 of whom developed CO-induced parkinsonism, and to discuss the possible underlying pathophysiological mechanism of CO-induced parkinsonism by comparing the neuroimaging findings of these patients. DESIGN AND SETTING: Case report from a clinical neurology department. PATIENTS: A married couple experienced CO poisoning simultaneously. One month later, only the husband gradually developed delayed sequelae, including parkinsonism and intellectual impairment. On detailed neurological examination, the husband showed mild but definite rigidity and bradykinesia, while no parkinsonian signs were observed in the wife. Neuropsychological examination revealed impaired memory and attention in both patients, but they were more severe in the husband than in the wife. Magnetic resonance imaging scans of the patients' brains disclosed diffuse high-intensity white matter signals in both patients and bilateral pallidal necrosis in the wife. Dopamine transporter imaging showed that the degree of dopamine neuronal loss was comparable between these patients. Magnetic resonance spectroscopy revealed more severe white matter damage in the husband than in the wife. Thirteen months later, neurological and neuropsychological examinations showed complete recovery from parkinsonism as well as intellectual impairment. Follow-up magnetic resonance spectroscopy also suggested remarkable improvements in white matter damage. CONCLUSION: These results support the role of white matter damage in producing parkinsonism after CO poisoning and highlight the possible usefulness of magnetic resonance spectroscopy in predicting delayed sequelae in patients after CO poisoning. Arch Neurol. 2000;57:1214-1218
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.