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Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model

DC FieldValueLanguage
dc.contributor.author김용욱-
dc.contributor.author나동균-
dc.contributor.author노태석-
dc.contributor.author윤인식-
dc.contributor.author이원재-
dc.date.accessioned2019-10-28T02:09:15Z-
dc.date.available2019-10-28T02:09:15Z-
dc.date.issued2019-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171509-
dc.description.abstractPURPOSE: Relaxin (RLX) is a transforming growth factor-β1 (TGF-β1) antagonist that is believed to function as a potent collagen re-arranger and a major suppressor of extracellular matrix components. Adenoviruses (Ads) are accepted vectors for cancer gene therapy. However, repeated treatments of Ad are limited by short-term biological activity in vivo. The efficacy of sustained RLX expression to scar remodeling was assessed using an injectable alginate gel-matrix system. MATERIALS AND METHODS: Pig scar tissue was treated with relaxin-expressing Ad loaded in alginate gel (gel/Ad-RLX). Surface areas, color, and pliability of scars were compared, and various factors influencing scar formation and collagen arrangement were analyzed. RESULTS: Gel/Ad-RLX decreased scar size, color index, and pliability. Immunohistochemistry showed decreased levels of major extracellular matrix proteins in the gel/Ad-RLX-treated group. Furthermore, treatment with gel/Ad-RLX reduced expression of tissue inhibitor of metalloproteinase-1 and alpha-smooth muscle actin and markedly increased expression of matrix metalloproteinase-1 in pig scar tissues. Gel/Ad-RLX also significantly downregulated TGF-β1 and upregulated TGF-β3 mRNAs in pig scar tissues. CONCLUSION: These results support a prominent role for RLX in scar remodeling and suggest that gel/Ad-RLX may have therapeutic effects on scar formation.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdenoviridae/genetics*-
dc.subject.MESHAdenoviridae/metabolism*-
dc.subject.MESHAlginates*-
dc.subject.MESHAnimals-
dc.subject.MESHCicatrix/metabolism-
dc.subject.MESHCicatrix/therapy*-
dc.subject.MESHCollagen/metabolism*-
dc.subject.MESHExtracellular Matrix/metabolism-
dc.subject.MESHMatrix Metalloproteinase 1-
dc.subject.MESHRelaxin/genetics*-
dc.subject.MESHRelaxin/metabolism*-
dc.subject.MESHRelaxin/pharmacology-
dc.subject.MESHSwine-
dc.subject.MESHTissue Inhibitor of Metalloproteinase-1-
dc.subject.MESHTransforming Growth Factor beta1-
dc.titleEffect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Plastic and Reconstructive Surgery (성형외과학교실)-
dc.contributor.googleauthorIn Sik Yun-
dc.contributor.googleauthorEunhye Kang-
dc.contributor.googleauthorHyo Min Ahn-
dc.contributor.googleauthorYong Oock Kim-
dc.contributor.googleauthorDong Kyun Rah-
dc.contributor.googleauthorTai Suk Roh-
dc.contributor.googleauthorWon Jai Lee-
dc.contributor.googleauthorChae-Ok Yun-
dc.identifier.doi10.3349/ymj.2019.60.9.854-
dc.contributor.localIdA00749-
dc.contributor.localIdA01229-
dc.contributor.localIdA01229-
dc.contributor.localIdA01297-
dc.contributor.localIdA01297-
dc.contributor.localIdA02588-
dc.contributor.localIdA02588-
dc.contributor.localIdA03005-
dc.contributor.localIdA03005-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid31433583-
dc.subject.keywordGene therapy-
dc.subject.keywordadenovirus-
dc.subject.keywordalginate gel-
dc.subject.keywordpig scar model-
dc.subject.keywordrelaxin-
dc.subject.keywordscar remodeling-
dc.contributor.alternativeNameKim, Yong Oock-
dc.contributor.affiliatedAuthor김용욱-
dc.contributor.affiliatedAuthor나동균-
dc.contributor.affiliatedAuthor나동균-
dc.contributor.affiliatedAuthor노태석-
dc.contributor.affiliatedAuthor노태석-
dc.contributor.affiliatedAuthor윤인식-
dc.contributor.affiliatedAuthor윤인식-
dc.contributor.affiliatedAuthor이원재-
dc.contributor.affiliatedAuthor이원재-
dc.citation.volume60-
dc.citation.number9-
dc.citation.startPage854-
dc.citation.endPage863-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.60(9) : 854-863, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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