Cited 6 times in
Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model
DC Field | Value | Language |
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dc.contributor.author | 김용욱 | - |
dc.contributor.author | 나동균 | - |
dc.contributor.author | 노태석 | - |
dc.contributor.author | 윤인식 | - |
dc.contributor.author | 이원재 | - |
dc.date.accessioned | 2019-10-28T02:09:15Z | - |
dc.date.available | 2019-10-28T02:09:15Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171509 | - |
dc.description.abstract | PURPOSE: Relaxin (RLX) is a transforming growth factor-β1 (TGF-β1) antagonist that is believed to function as a potent collagen re-arranger and a major suppressor of extracellular matrix components. Adenoviruses (Ads) are accepted vectors for cancer gene therapy. However, repeated treatments of Ad are limited by short-term biological activity in vivo. The efficacy of sustained RLX expression to scar remodeling was assessed using an injectable alginate gel-matrix system. MATERIALS AND METHODS: Pig scar tissue was treated with relaxin-expressing Ad loaded in alginate gel (gel/Ad-RLX). Surface areas, color, and pliability of scars were compared, and various factors influencing scar formation and collagen arrangement were analyzed. RESULTS: Gel/Ad-RLX decreased scar size, color index, and pliability. Immunohistochemistry showed decreased levels of major extracellular matrix proteins in the gel/Ad-RLX-treated group. Furthermore, treatment with gel/Ad-RLX reduced expression of tissue inhibitor of metalloproteinase-1 and alpha-smooth muscle actin and markedly increased expression of matrix metalloproteinase-1 in pig scar tissues. Gel/Ad-RLX also significantly downregulated TGF-β1 and upregulated TGF-β3 mRNAs in pig scar tissues. CONCLUSION: These results support a prominent role for RLX in scar remodeling and suggest that gel/Ad-RLX may have therapeutic effects on scar formation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | Yonsei Medical Journal | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adenoviridae/genetics* | - |
dc.subject.MESH | Adenoviridae/metabolism* | - |
dc.subject.MESH | Alginates* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cicatrix/metabolism | - |
dc.subject.MESH | Cicatrix/therapy* | - |
dc.subject.MESH | Collagen/metabolism* | - |
dc.subject.MESH | Extracellular Matrix/metabolism | - |
dc.subject.MESH | Matrix Metalloproteinase 1 | - |
dc.subject.MESH | Relaxin/genetics* | - |
dc.subject.MESH | Relaxin/metabolism* | - |
dc.subject.MESH | Relaxin/pharmacology | - |
dc.subject.MESH | Swine | - |
dc.subject.MESH | Tissue Inhibitor of Metalloproteinase-1 | - |
dc.subject.MESH | Transforming Growth Factor beta1 | - |
dc.title | Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Plastic and Reconstructive Surgery (성형외과학교실) | - |
dc.contributor.googleauthor | In Sik Yun | - |
dc.contributor.googleauthor | Eunhye Kang | - |
dc.contributor.googleauthor | Hyo Min Ahn | - |
dc.contributor.googleauthor | Yong Oock Kim | - |
dc.contributor.googleauthor | Dong Kyun Rah | - |
dc.contributor.googleauthor | Tai Suk Roh | - |
dc.contributor.googleauthor | Won Jai Lee | - |
dc.contributor.googleauthor | Chae-Ok Yun | - |
dc.identifier.doi | 10.3349/ymj.2019.60.9.854 | - |
dc.contributor.localId | A00749 | - |
dc.contributor.localId | A01229 | - |
dc.contributor.localId | A01297 | - |
dc.contributor.localId | A02588 | - |
dc.contributor.localId | A03005 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 31433583 | - |
dc.subject.keyword | Gene therapy | - |
dc.subject.keyword | adenovirus | - |
dc.subject.keyword | alginate gel | - |
dc.subject.keyword | pig scar model | - |
dc.subject.keyword | relaxin | - |
dc.subject.keyword | scar remodeling | - |
dc.contributor.alternativeName | Kim, Yong Oock | - |
dc.contributor.affiliatedAuthor | 김용욱 | - |
dc.contributor.affiliatedAuthor | 나동균 | - |
dc.contributor.affiliatedAuthor | 노태석 | - |
dc.contributor.affiliatedAuthor | 윤인식 | - |
dc.contributor.affiliatedAuthor | 이원재 | - |
dc.citation.volume | 60 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 854 | - |
dc.citation.endPage | 863 | - |
dc.identifier.bibliographicCitation | Yonsei Medical Journal, Vol.60(9) : 854-863, 2019 | - |
dc.identifier.rimsid | 63793 | - |
dc.type.rims | ART | - |
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