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Radially patterned polycaprolactone nanofibers as an active wound dressing agent

DC FieldValueLanguage
dc.contributor.author노태석-
dc.contributor.author이원재-
dc.contributor.author백우열-
dc.contributor.author신동우-
dc.date.accessioned2019-10-28T02:08:16Z-
dc.date.available2019-10-28T02:08:16Z-
dc.date.issued2019-
dc.identifier.issn2234-6163-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171504-
dc.description.abstractBACKGROUND: The objectives of this study were to design polycaprolactone nanofibers with a radial pattern using a modified electrospinning method and to evaluate the effect of radial nanofiber deposition on mechanical and biological properties compared to non-patterned samples. METHODS: Radially patterned polycaprolactone nanofibers were prepared with a modified electrospinning method and compared with randomly deposited nanofibers. The surface morphology of samples was observed under scanning electron microscopy (SEM). The tensile properties of nanofibrous mats were measured using a tabletop uniaxial testing machine. Fluorescence-stained human bone marrow stem cells were placed along the perimeter of the radially patterned and randomly deposited. Their migration toward the center was observed on days 1, 4, and 7, and quantitatively measured using ImageJ software. RESULTS: Overall, there were no statistically significant differences in mechanical properties between the two types of polycaprolactone nanofibrous mats. SEM images of the obtained samples suggested that the directionality of the nanofibers was toward the central area, regardless of where the nanofibers were located throughout the entire sample. Florescence images showed stronger fluorescence inside the circle in radially aligned nanofibers, with significant differences on days 4 and 7, indicating that migration was quicker along radially aligned nanofibers than along randomly deposited nanofibers. CONCLUSIONS: In this study, we successfully used modified electrospinning to fabricate radially aligned nanofibers with similar mechanical properties to those of conventional randomly aligned nanofibers. In addition, we observed faster migration along radially aligned nanofibers than along randomly deposited nanofibers. Collectively, the radially aligned nanofibers may have the potential for tissue regeneration in combination with stem cells.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society of Plastic and Reconstructive Surgeons-
dc.relation.isPartOfArchives of Plastic Surgery-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleRadially patterned polycaprolactone nanofibers as an active wound dressing agent-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Plastic and Reconstructive Surgery (성형외과학교실)-
dc.contributor.googleauthorDongwoo Shin-
dc.contributor.googleauthorMin Sup Kim-
dc.contributor.googleauthorChae Eun Yang-
dc.contributor.googleauthorWon Jai Lee-
dc.contributor.googleauthorTai Suk Roh-
dc.contributor.googleauthorWooyeol Ba다-
dc.identifier.doi10.5999/aps.2019.00626-
dc.contributor.localIdA01297-
dc.contributor.localIdA03005-
dc.contributor.localIdA03005-
dc.contributor.localIdA04949-
dc.contributor.localIdA04949-
dc.contributor.localIdA05775-
dc.contributor.localIdA05775-
dc.relation.journalcodeJ00231-
dc.identifier.eissn2234-6171-
dc.identifier.pmid31550744-
dc.subject.keywordNanofibers-
dc.subject.keywordPolycaprolactone-
dc.subject.keywordPolymers-
dc.subject.keywordWound healing-
dc.contributor.alternativeNameRoh, Tai Suk-
dc.contributor.affiliatedAuthor노태석-
dc.contributor.affiliatedAuthor이원재-
dc.contributor.affiliatedAuthor이원재-
dc.contributor.affiliatedAuthor백우열-
dc.contributor.affiliatedAuthor백우열-
dc.contributor.affiliatedAuthor신동우-
dc.contributor.affiliatedAuthor신동우-
dc.citation.volume46-
dc.citation.number5-
dc.citation.startPage399-
dc.citation.endPage404-
dc.identifier.bibliographicCitationArchives of Plastic Surgery, Vol.46(5) : 399-404, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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