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Evolutionary mechanism leading to the multi-cagA genotype in Helicobacter pylori

DC FieldValueLanguage
dc.contributor.author차정헌-
dc.date.accessioned2019-10-28T02:06:23Z-
dc.date.available2019-10-28T02:06:23Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171488-
dc.description.abstractInfection with CagA+ Helicobacter pylori strains is linked to an increased risk for gastric diseases, including gastric cancer. Recent evidence indicates that dynamic expansion and contraction of cagA copy number may serve as a novel mechanism to enhance disease development. Herein, comparative genomic analysis divided hpEurope into two groups: hpEurope/type-A and type-B. Only hpEurope/type-B displayed the multi-cagA genotype. Further analysis showed that cagPAI appears to have been independently introduced into two different H. pylori types, termed pre-type-A and pre-type-B, which consequently evolved to cagPAI type-A and type-B, respectively; importantly, all multi-cagA genotype strains displayed cagPAI type-B. Two direct cagA-flanking repeats of a genetic element termed CHA-ud were essential for the multi-cagA genotype in strain PMSS1 (hpEurope/type-B and cagPAI type-B). Furthermore, introduction of this genetic element into strain G27 (hpEurope/type-A and cagPAI type-A) was sufficient to generate the multi-cagA genotype. The critical steps in the evolution of the multi-cagA genotype involved creation of CHA-ud at cagA upstream in cagPAI type-B strains followed by its duplication to cagA downstream. En masse, elucidation of the mechanism by which H. pylori evolved to carry multiple copies of cagA helps to provide a better understanding of how this ancient pathogen interacts with its host.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfScientific Reports-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEvolutionary mechanism leading to the multi-cagA genotype in Helicobacter pylori-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorHanfu Su-
dc.contributor.googleauthorKavinda Tissera-
dc.contributor.googleauthorSungil Jang-
dc.contributor.googleauthorYun Hui Choi-
dc.contributor.googleauthorAeryun Kim-
dc.contributor.googleauthorYong-Joon Cho-
dc.contributor.googleauthorMeiling Li-
dc.contributor.googleauthorNiluka Gunawardhana-
dc.contributor.googleauthorD. Scott Merrell-
dc.contributor.googleauthorLinhu Ge-
dc.contributor.googleauthorJeong-Heon Cha-
dc.identifier.doi10.1038/s41598-019-47240-2-
dc.contributor.localIdA04007-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid31371778-
dc.contributor.alternativeNameCha, Jung Heon-
dc.contributor.affiliatedAuthor차정헌-
dc.citation.volume9-
dc.citation.number1-
dc.citation.startPage11203-
dc.identifier.bibliographicCitationScientific Reports, Vol.9(1) : 11203, 2019-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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