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High A20 expression negatively impacts survival in patients with breast cancer

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dc.contributor.author안성귀-
dc.contributor.author이혜선-
dc.contributor.author정준-
dc.contributor.author배숭준-
dc.contributor.author박소은-
dc.contributor.author차치환-
dc.date.accessioned2019-10-28T02:03:47Z-
dc.date.available2019-10-28T02:03:47Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171465-
dc.description.abstractBACKGROUND: A20 protein has ubiquitin-editing activities and acts as a key regulator of inflammation and immunity. Previously, our group showed that A20 promotes tumor metastasis through multi-monoubiquitylation of SNAIL1 in basal-like breast cancer. Here, we investigated survival outcomes in patients with breast cancer according to A20 expression. PATIENTS AND METHODS: We retrospectively collected tumor samples from patients with breast cancer. Immunohistochemistry (IHC) with an A20-specific antibody was performed, and survival outcomes were analyzed. RESULTS: A20 expression was evaluated in 442 patients. High A20 expression was associated with advanced anatomical stage and young age. High A20 expression showed significantly inferior recurrence-free-survival and overall-survival (P<0.001 and P<0.001, respectively). Multivariate analysis showed that A20 was an independent prognostic marker for RFS (HRs: 2.324, 95% CIs: 1.446-3.736) and OS (HRs: 2.629, 95% CIs: 1.585-4.361). In human epidermal growth factor receptor 2 (HER2)-positive and triple negative breast cancer (TNBC) subtypes, high A20 levels were associated with poor OS. CONCLUSION: We found that A20 expression is a poor prognostic marker in breast cancer. The prognostic impact of A20 was pronounced in aggressive tumors, such as HER2-positive and TNBC subtypes. Our findings suggested that A20 may be a valuable target in patients with aggressive breast cancer.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHigh A20 expression negatively impacts survival in patients with breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorChang Ik Yoon-
dc.contributor.googleauthorSung Gwe Ahn-
dc.contributor.googleauthorSoong June Bae-
dc.contributor.googleauthorYun Jin Shin-
dc.contributor.googleauthorChihwan Cha-
dc.contributor.googleauthorSo Eun Park-
dc.contributor.googleauthorJi-Hyung Lee-
dc.contributor.googleauthorAkira Ooshima-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorKyung-Min Yang-
dc.contributor.googleauthorSeong-Jin Kim-
dc.contributor.googleauthorSeok Hee Park-
dc.contributor.googleauthorJoon Jeong-
dc.identifier.doi10.1371/journal.pone.0221721-
dc.contributor.localIdA02231-
dc.contributor.localIdA03312-
dc.contributor.localIdA03312-
dc.contributor.localIdA03727-
dc.contributor.localIdA03727-
dc.contributor.localIdA05345-
dc.contributor.localIdA05345-
dc.contributor.localIdA05726-
dc.contributor.localIdA05726-
dc.contributor.localIdA05731-
dc.contributor.localIdA05731-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid31449546-
dc.contributor.alternativeNameAhn, Sung Gwe-
dc.contributor.affiliatedAuthor안성귀-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor정준-
dc.contributor.affiliatedAuthor정준-
dc.contributor.affiliatedAuthor배숭준-
dc.contributor.affiliatedAuthor배숭준-
dc.contributor.affiliatedAuthor박소은-
dc.contributor.affiliatedAuthor박소은-
dc.contributor.affiliatedAuthor차치환-
dc.contributor.affiliatedAuthor차치환-
dc.citation.volume14-
dc.citation.number8-
dc.citation.startPagee0221721-
dc.identifier.bibliographicCitationPLoS One, Vol.14(8) : e0221721, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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