Cited 16 times in
High A20 expression negatively impacts survival in patients with breast cancer
DC Field | Value | Language |
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dc.contributor.author | 안성귀 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 정준 | - |
dc.contributor.author | 배숭준 | - |
dc.contributor.author | 박소은 | - |
dc.contributor.author | 차치환 | - |
dc.date.accessioned | 2019-10-28T02:03:47Z | - |
dc.date.available | 2019-10-28T02:03:47Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171465 | - |
dc.description.abstract | BACKGROUND: A20 protein has ubiquitin-editing activities and acts as a key regulator of inflammation and immunity. Previously, our group showed that A20 promotes tumor metastasis through multi-monoubiquitylation of SNAIL1 in basal-like breast cancer. Here, we investigated survival outcomes in patients with breast cancer according to A20 expression. PATIENTS AND METHODS: We retrospectively collected tumor samples from patients with breast cancer. Immunohistochemistry (IHC) with an A20-specific antibody was performed, and survival outcomes were analyzed. RESULTS: A20 expression was evaluated in 442 patients. High A20 expression was associated with advanced anatomical stage and young age. High A20 expression showed significantly inferior recurrence-free-survival and overall-survival (P<0.001 and P<0.001, respectively). Multivariate analysis showed that A20 was an independent prognostic marker for RFS (HRs: 2.324, 95% CIs: 1.446-3.736) and OS (HRs: 2.629, 95% CIs: 1.585-4.361). In human epidermal growth factor receptor 2 (HER2)-positive and triple negative breast cancer (TNBC) subtypes, high A20 levels were associated with poor OS. CONCLUSION: We found that A20 expression is a poor prognostic marker in breast cancer. The prognostic impact of A20 was pronounced in aggressive tumors, such as HER2-positive and TNBC subtypes. Our findings suggested that A20 may be a valuable target in patients with aggressive breast cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLoS One | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | High A20 expression negatively impacts survival in patients with breast cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Chang Ik Yoon | - |
dc.contributor.googleauthor | Sung Gwe Ahn | - |
dc.contributor.googleauthor | Soong June Bae | - |
dc.contributor.googleauthor | Yun Jin Shin | - |
dc.contributor.googleauthor | Chihwan Cha | - |
dc.contributor.googleauthor | So Eun Park | - |
dc.contributor.googleauthor | Ji-Hyung Lee | - |
dc.contributor.googleauthor | Akira Ooshima | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Kyung-Min Yang | - |
dc.contributor.googleauthor | Seong-Jin Kim | - |
dc.contributor.googleauthor | Seok Hee Park | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.identifier.doi | 10.1371/journal.pone.0221721 | - |
dc.contributor.localId | A02231 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A03727 | - |
dc.contributor.localId | A05345 | - |
dc.contributor.localId | A05726 | - |
dc.contributor.localId | A05731 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 31449546 | - |
dc.contributor.alternativeName | Ahn, Sung Gwe | - |
dc.contributor.affiliatedAuthor | 안성귀 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | 정준 | - |
dc.contributor.affiliatedAuthor | 배숭준 | - |
dc.contributor.affiliatedAuthor | 박소은 | - |
dc.contributor.affiliatedAuthor | 차치환 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | e0221721 | - |
dc.identifier.bibliographicCitation | PLoS One, Vol.14(8) : e0221721, 2019 | - |
dc.identifier.rimsid | 63880 | - |
dc.type.rims | ART | - |
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