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Effect of Specific Retinoic Acid Receptor Agonists on Noise-Induced Hearing Loss

 Sang Hyun Kwak  ;  Gi-Sung Nam  ;  Seong Hoon Bae  ;  Jinsei Jung 
 International Journal of Environmental Research and Public Health, Vol.16(18) : E3428, 2019 
Journal Title
 International Journal of Environmental Research and Public Health 
Issue Date
Noise-induced hearing loss ; retinoic acid ; selective RAR agonists ; sensorineural hearing loss
Noise is one of the most common causes of hearing loss in industrial countries. There are many studies about chemical agents to prevent noise-induced hearing loss (NIHL). However, there is no commercially available drug yet. Retinoic acid is an active metabolite of Vitamin A; it has an anti-apoptic role in NIHL. This study aims to verify the differences among selective agonists of retinoic acid receptors (RARs) in NIHL. All-trans retinoic acid (ATRA), AM80 (selective retinoic acid receptor α agonist), AC261066 (Selective retinoic acid receptor β1 agonist), and CD1530 (Selective retinoic acid λ agonist) were injected to 6-7 weeks old CJ5BL/6 mice before noise (110 dB for 3 h) exposure. In the auditory brainstem response test pre-, post 1, 3, and 7 days after noise exposure, not only ATRA but all kinds of selective RAR agonists showed protective effects in hearing threshold and wave I amplitude. Though there was no significant difference in the level of protective effects between agonists, α agonist showed the most prominent effect in preserving hearing function as well as outer hair cells after noise exposure. In conclusion, selective agonists of RAR demonstrate comparable protective effects against NIHL to retinoic acid. Given that these selective RAR agonists have less side effects than retinoic acid, they may be promising potential drugs against NIHL.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Bae, Seong Hoon(배성훈)
Jung, Jinsei(정진세) ORCID logo https://orcid.org/0000-0003-1906-6969
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