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Prognosis of non-small-cell lung cancer in patients with idiopathic pulmonary fibrosis

Authors
 SongYi Han  ;  Yeon Joo Lee  ;  Jong Sun Park  ;  Young-Jae Cho  ;  Ho Il Yoon  ;  Jae-Ho Lee  ;  Choon-Taek Lee  ;  Jin-Haeng Chung  ;  Kyung Won Lee  ;  Sang Hoon Lee 
Citation
 Scientific Reports, Vol.9(1) : 12561, 2019 
Journal Title
 Scientific Reports 
Issue Date
2019
Abstract
The risk of lung cancer is higher in idiopathic pulmonary fibrosis (IPF) because both conditions share common risk factors. However, no standard treatment modality for LC in IPF exists due to rare incidence, poor prognosis, and acute exacerbation (AE) of IPF during treatment. We aimed to determine the efficacy of LC treatments and the prognosis in LC patients with IPF according to the LC stage and GAP (gender [G], age [A], and two physiology variables [P]) stage. From 2003 to 2016, 160 retrospectively enrolled patients were classified according to the LC clinical stage and GAP stage. The average (±standard deviation) patient age was 70.1 ± 8.2 years; the cohort predominantly comprised men (94.4%). In GAP stage I, surgery was significantly associated with better survival outcomes in LC. In contrast, no treatment modality yielded significant clinical improvement in GAP stage II/III. The incidences of AE in IPF and its mortality during treatment were 13.8% and 6.3%, respectively. AE occurred commonly in advanced GAP stage. Active treatment should be considered in GAP stage I. The performance status and LC stage should be considered when deciding about the necessity of surgery for patients in advanced GAP stage.
Files in This Item:
T201903567.pdf Download
DOI
10.1038/s41598-019-49026-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Hoon(이상훈) ORCID logo https://orcid.org/0000-0002-7706-5318
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171447
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