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Maternal Perinatal Dietary Patterns Affect Food Allergy Development in Susceptible Infants

Authors
 Yoon Hee Kim  ;  Kyung Won Kim  ;  So-Yeon Lee  ;  Kyeong Ok Koo  ;  Sung-Ok Kwon  ;  Ju-Hee Seo  ;  Dong In Suh  ;  Youn Ho Shin  ;  Kangmo Ahn  ;  Se-Young Oh  ;  Sooyoung Lee  ;  Myung Hyun Sohn  ;  Soo-Jong Hong 
Citation
 Journal of Allergy and Clinical Immunology. In Practice, Vol.7(7) : 2337-2347.e7, 2019 
Journal Title
 Journal of Allergy and Clinical Immunology. In Practice 
ISSN
 2213-2198 
Issue Date
2019
Keywords
CD14 ; Confectionary ; Dietary pattern ; Fatty acids ; Food allergy ; GST ; Genetics ; Infant ; Perinatal ; Polymorphism
Abstract
BACKGROUND: The increasing incidence of food allergy (FA) can be attributed to interactions between genes and the environment, but these interactions are not yet fully clear. OBJECTIVE: We aimed to evaluate the interaction between infant genetic variations and maternal dietary patterns to identify risk factors in the development of FA. METHODS: We used the Cohort for Childhood Origin of Asthma and allergic diseases birth cohort of 1628 infants, born between 2007 and 2015. Maternal dietary intakes were assessed at 26 weeks of pregnancy using a food frequency questionnaire and grouped according to 5 dietary patterns. Infant cord blood samples were genotyped at 12 loci. RESULTS: Among 1628 infants, 147 (9.0%) were diagnosed with FA based on history. A maternal confectionery diet characterized by a higher intake of baked and sugary products during pregnancy was associated with a higher prevalence of FA (adjusted odds ratio [OR] = 1.517, P = .02); this dietary pattern tended to be higher in trans fat (r = 0.498, P < .001). Development of FA was associated with longer periods of breastfeeding (adjusted OR = 1.792, P = .03), and this dietary pattern was more significantly related to the development of FA in infants with the homozygous TT genotype of CD14 (rs2569190) and more than 1 copy of GSTM1 and GSTT1. CONCLUSIONS: A maternal confectionery diet during pregnancy that majorly consists of baked and sugary products, combined with a longer ensuing period of breastfeeding, may lead to the development of FA, suggesting a harmful effect of trans fats in the infant. Polymorphisms in CD14 and GST in the infant influence FA susceptibility.
Full Text
https://www.sciencedirect.com/science/article/pii/S2213219819303071
DOI
10.1016/j.jaip.2019.03.026
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Yoon Hee(김윤희) ORCID logo https://orcid.org/0000-0002-2149-8501
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171410
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