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Anti-Tumor Potential of a 5-HT3 Receptor Antagonist as a Novel Autophagy Inducer in Lung Cancer: A Retrospective Clinical Study with In Vitro Confirmation

DC FieldValueLanguage
dc.contributor.author김나영-
dc.contributor.author박성용-
dc.contributor.author유영철-
dc.contributor.author이정수-
dc.contributor.author이종석-
dc.contributor.author오주은-
dc.date.accessioned2019-10-28T01:55:24Z-
dc.date.available2019-10-28T01:55:24Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171406-
dc.description.abstractUnlike 5-hydroxytryptamine (5-HT, serotonin) 1 and 5-HT2, the effect of 5-HT3 receptors on tumor cells is poorly understood. We conducted this study to determine whether the perioperative use of 5-HT3 receptor antagonists, which are widely used antiemetics, impacts the recurrence and mortality after lung cancer surgery and related anti-tumor mechanisms. From data on 411 patients, propensity score matching was used to produce 60 1:2 matched pairs of patients, and variables associated with the prognosis after open lung cancer surgery were analyzed. Additionally, the effects of 5-HT3 receptor antagonists were confirmed in vitro on A549 human lung adenocarcinoma cells. Cancer recurrence occurred in 10 (8.2%) and 14 (22.95%) patients (p = 0.005), treated or untreated, with palonosetron or ramosetron. Perioperative usage of palonosetron or ramosetron was also associated with lower recurrence rate after lung cancer surgery (hazard ratio (HR), 0.293; 95% confidence interval (CI) 0.110-0.780, p = 0.0141). Our in vitro experiments also showed that palonosetron and ramosetron inhibited cell proliferation and colony formation and reduced migration, which was associated with autophagic cell death via the extracellular signal-regulated kinase (ERK) pathway. Palonosetron and ramosetron may have anti-tumor potential against lung cancer cells, suggesting the need to consider these drugs as first-choice antiemetics in patients undergoing lung cancer surgery.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJournal of Clinical Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAnti-Tumor Potential of a 5-HT3 Receptor Antagonist as a Novel Autophagy Inducer in Lung Cancer: A Retrospective Clinical Study with In Vitro Confirmation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorJeong Soo Lee-
dc.contributor.googleauthorSeong Yong Park-
dc.contributor.googleauthorNa Young Kim-
dc.contributor.googleauthorDong Wook Kim-
dc.contributor.googleauthorJu Eun Oh-
dc.contributor.googleauthorEunjin Heo-
dc.contributor.googleauthorJong Seok Lee-
dc.contributor.googleauthorYoung Chul Yoo-
dc.identifier.doi10.3390/jcm8091380-
dc.contributor.localIdA00348-
dc.contributor.localIdA01508-
dc.contributor.localIdA01508-
dc.contributor.localIdA02484-
dc.contributor.localIdA02484-
dc.contributor.localIdA03109-
dc.contributor.localIdA03109-
dc.contributor.localIdA03141-
dc.contributor.localIdA03141-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid31484445-
dc.subject.keywordlung neoplasm-
dc.subject.keywordpalonosetron-
dc.subject.keywordramosetron-
dc.subject.keywordserotonin antagonist-
dc.contributor.alternativeNameKim, Na Young-
dc.contributor.affiliatedAuthor김나영-
dc.contributor.affiliatedAuthor박성용-
dc.contributor.affiliatedAuthor박성용-
dc.contributor.affiliatedAuthor유영철-
dc.contributor.affiliatedAuthor유영철-
dc.contributor.affiliatedAuthor이정수-
dc.contributor.affiliatedAuthor이정수-
dc.contributor.affiliatedAuthor이종석-
dc.contributor.affiliatedAuthor이종석-
dc.citation.volume8-
dc.citation.number9-
dc.citation.startPageE1380-
dc.identifier.bibliographicCitationJournal of Clinical Medicine, Vol.8(9) : E1380, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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