Cited 1 times in
Survey of IgE Reactivity to Nonbiting Midges in Korea and Identification of IgE-Binding Protein
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김주영 | - |
dc.contributor.author | 용태순 | - |
dc.contributor.author | 이명희 | - |
dc.contributor.author | 이한일 | - |
dc.contributor.author | 정경용 | - |
dc.date.accessioned | 2019-10-28T01:36:51Z | - |
dc.date.available | 2019-10-28T01:36:51Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171271 | - |
dc.description.abstract | PURPOSE: Chironomids (nonbiting midges) are widely and abundantly distributed near ponds, rivers, and artificially dammed pools used for irrigation. Chironomids contain allergens and cause airway allergy in humans. In this study, we aimed to examine the allergic potential of chironomids in inhabitants living near artificially dammed pools. METHODS: We examined immunoglobulin E (IgE) reactivity to chironomid extracts in the sera of residents living around installed dams and assessed the correlations of IgE responses between chironomids (Chironomus flaviplumus, Chironomus kiiensis, Cricotopus bicinctus) and house dust mites (Dermatophagoides farinae). In addition, we identified potential IgE binding proteins specific for adult C. bicinctus, a popular species in Korea. Specific IgE antibodies in sera collected from the participants against the extracts were tested using enzyme-linked immunosorbent assay (ELISA). RESULTS: The average IgE-positive rates were 10.4%, 8.1%, and 8.2% in C. bicinctus, C. flaviplumus, and C. kiiensis, respectively. The IgE-positive rate and IgE titer of C. bicinctus antigen were higher in residents living around installed dams than in those who lived other places (P = 0.013). Western blotting using sera having high IgE titers to C. bicinctus in ELISA showed the presence of a protein of approximately 42 kDa that was homologous to the actin protein isoform in C. bicinctus extracts as demonstrated using mass spectrometry. CONCLUSIONS: Our results showed that people living near installed dams were more sensitized to C. bicinctus and that the 42 kDa IgE-binding protein could be useful for further studies on chironomid allergic disease and clinical applications. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Korean Academy of Pediatric Allergy and Respiratory Disease | - |
dc.relation.isPartOf | Allergy Asthma & Immunology Research | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Survey of IgE Reactivity to Nonbiting Midges in Korea and Identification of IgE-Binding Protein | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Tropica Medicine (열대의학교실) | - |
dc.contributor.googleauthor | Myung-hee Yi | - |
dc.contributor.googleauthor | Ju Yeong Kim | - |
dc.contributor.googleauthor | Kyoung Yong Jeong | - |
dc.contributor.googleauthor | Han-Il Ree | - |
dc.contributor.googleauthor | Tai-Soon Yong | - |
dc.identifier.doi | 10.4168/aair.2019.11.5.644 | - |
dc.contributor.localId | A00937 | - |
dc.contributor.localId | A02424 | - |
dc.contributor.localId | A02761 | - |
dc.contributor.localId | A03279 | - |
dc.contributor.localId | A03572 | - |
dc.relation.journalcode | J00064 | - |
dc.identifier.eissn | 2092-7363 | - |
dc.identifier.pmid | 31332976 | - |
dc.subject.keyword | IgE binding protein | - |
dc.subject.keyword | Nonbiting midges | - |
dc.subject.keyword | allergy | - |
dc.contributor.alternativeName | Kim, Ju Young | - |
dc.contributor.affiliatedAuthor | 김주영 | - |
dc.contributor.affiliatedAuthor | 용태순 | - |
dc.contributor.affiliatedAuthor | 이명희 | - |
dc.contributor.affiliatedAuthor | 이한일 | - |
dc.contributor.affiliatedAuthor | 정경용 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 644 | - |
dc.citation.endPage | 654 | - |
dc.identifier.bibliographicCitation | Allergy Asthma & Immunology Research, Vol.11(5) : 644-654, 2019 | - |
dc.identifier.rimsid | 63861 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.