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Nanostructured TiO2 Materials for Analysis of Gout-Related Crystals Using Laser Desorption/Ionization Time-of-Flight (LDI-ToF) Mass Spectrometry

Authors
 Moon-Ju Kim  ;  Tae Gyeong Yun  ;  Jaeyong Jung  ;  Jong-Min Park  ;  Joo-Yoon Noh  ;  Jungsik Song  ;  Min-Jung Kang  ;  Jae-Chul Pyun Orcid , 
Citation
 Analytical Chemistry, Vol.91(17) : 11283-11290, 2019 
Journal Title
 Analytical Chemistry 
ISSN
 0003-2700 
Issue Date
2019
Abstract
Crystals of monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) are known to induce arthropathic diseases called gout and pseudogout, respectively. These crystals are deposited in various joints or tissues, causing severe pain. Correct identification of crystals is crucial for the appropriate treatment of gout and pseudogout, which exhibit very similar symptoms. Herein, a novel approach of laser desorption/ionization time-of-flight (LDI-ToF) mass spectrometry (MS) was introduced to analyze MSU and CPPD crystals with three different types of nanostructured TiO2 materials including TiO2 nanoparticles (P25), TiO2 nanowires synthesized from wet-corrosion method, and the mixture of P25 and TiO2 nanowires (P25/TiO2 nanowires) as inorganic solid matrices. Furthermore, the feasibility of LDI-ToF MS based on these TiO2 nanostructures for the analysis of the two arthropathy-related crystals was tested using spiked samples in synovial fluid at known crystal concentrations. The mass analysis results of MSU and CPPD crystals demonstrated that (1) the electrostatic interaction between analytes and solid matrices was key for the analyte ionization and (2) LDI-ToF MS with nanostructured TiO2 materials has the potential to be a practical approach for the diagnosis of gout and pseudogout.
Full Text
https://pubs.acs.org/doi/10.1021/acs.analchem.9b02231
DOI
10.1021/acs.analchem.9b02231
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Song, Jason Jungsik(송정식) ORCID logo https://orcid.org/0000-0003-0662-7704
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171228
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