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Snoring and incident chronic kidney disease: a community-based prospective cohort study

 Changhyun Lee  ;  Young Su Joo  ;  Sangmi Lee  ;  Shinchan Kang  ;  Joohwan Kim  ;  Ki Heon Nam  ;  Hae-Ryong Yun  ;  Jong Hyun Jhee  ;  Hyoungnae Kim  ;  Seung Hyeok Han  ;  Tae-Hyun Yoo  ;  Shin-Wook Kang  ;  Jung Tak Park 
 BMJ Open, Vol.9(8) : e030671, 2019 
Journal Title
 BMJ Open 
Issue Date
chronic renal failure ; risk factor ; snoring
OBJECTIVES: Previous studies have shown that symptoms of sleep-disordered breathing are associated with metabolic derangements and vascular disease development. However, the relationship between snoring and renal function is not well investigated. The association between snoring and the development of incident chronic kidney disease (CKD) in subjects with normal renal function was evaluated. DESIGN: Prospective cohort study. SETTING: Ansung (rural community) and Ansan (urban community) cities. PARTICIPANTS: Community-based cohort participants aged 40-69 years. METHODS: A total of 9062 participants in the Ansung-Ansan cohort study were prospectively followed up from 2001 to 2014. The participants were classified into three groups: non-snorer, <1 day/week and ≥1 day/week. The main outcome was incident CKD, which was defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m2 during the follow-up period. PRIMARY OUTCOME: Incident CKD. RESULTS: The mean subject age was 52.0±8.9 years, and 4372 (48.2%) subjects were male. The non-snorer,<1 day/week and ≥1 day/week groups included 3493 (38.5%), 3749 (41.4%), and 1820 (20.1%) subjects, respectively. Metabolic syndrome was more prevalent in the snoring groups than in the non-snoring group. Snoring frequency showed a significant positive relationship with age, waist:hip ratio, fasting glucose, total cholesterol (Tchol) and low-density lipoprotein cholesterol. During a mean follow-up of 8.9 years, 764 (8.4%) subjects developed CKD. Cox proportional hazards model analysis revealed that the risk of CKD development was significantly higher in subjects who snored ≥1 day/week than in non-snorers, even after adjustments for confounding factors (HR 1.23, 95% CI 1.09 to 1.38, p<0.01). CONCLUSION: Snoring may increase the risk of CKD development in subjects with normal renal function.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kang, Shinchan(강신찬)
Kim, Joohwan(김주환)
Kim, Hyoung Rae(김형래)
Nam, Ki Heon(남기헌) ORCID logo https://orcid.org/0000-0001-7312-7027
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Yun, Hae Ryong(윤해룡) ORCID logo https://orcid.org/0000-0002-7038-0251
Lee, Sangmi(이상미) ORCID logo https://orcid.org/0000-0002-3619-0809
Lee, Changhyun(이창현)
Joo, Young Su(주영수) ORCID logo https://orcid.org/0000-0002-7890-0928
Jhee, Jong Hyun(지종현)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
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