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Grey-white matter ratio measured using early unenhanced brain computed tomography shows no correlation with neurological outcomes in patients undergoing targeted temperature management after cardiac arrest
DC Field | Value | Language |
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dc.contributor.author | 박유석 | - |
dc.date.accessioned | 2019-09-20T07:51:35Z | - |
dc.date.available | 2019-09-20T07:51:35Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0300-9572 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171090 | - |
dc.description.abstract | AIM: This study evaluated whether the grey-white matter ratio (GWR) assessed via early brain computed tomography (CT) within 2 h after the return of spontaneous circulation (ROSC) following cardiac arrest is associated with poor neurological outcomes after 6 months in post-cardiac arrest patients treated with targeted temperature management (TTM). METHODS: This study used data from the Korean Hypothermia Network prospective registry obtained from November 2015 to October 2017 to assess patients with out-of-hospital cardiac arrest (OHCA) who underwent brain CT within 2 h following the ROSC. The primary endpoint was the neurological outcome 6 months post-cardiac arrest (cerebral performance category; CPC). The GWR was measured using early brain CT images. The subgroup analysis examined the difference in GWRs obtained from early and repeated brain CT. RESULTS: Five-hundred-twelve patients were enrolled. Good (CPC 1-2) and poor (CPC 3-5) neurological outcomes were observed in 162 (31.6%) and 350 (68.4%) patients, respectively. The multivariate logistic regression analysis revealed that the GWR measured using early brain CT was a statistically nonsignificant predictor of poor neurologic outcomes (p = 0.727). In patients with poor outcomes, the mean GWR obtained from early and repeated CT images were 1.171 ± 0.058 and 1.091 ± 0.133, respectively (p < 0.001); there was no statistically significant difference between the GWRs in patients with good outcomes. CONCLUSION: The GWR assessed via early brain CT alone is not an independent factor predictive of poor neurologic outcomes but could be useful when used with repeated CT data. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier/north-Holland Biomedical Press | - |
dc.relation.isPartOf | Resuscitation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Grey-white matter ratio measured using early unenhanced brain computed tomography shows no correlation with neurological outcomes in patients undergoing targeted temperature management after cardiac arrest | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Emergency Medicine (응급의학교실) | - |
dc.contributor.googleauthor | Jun Young Hong | - |
dc.contributor.googleauthor | Dong Hoon Lee | - |
dc.contributor.googleauthor | Je Hyeok Oh | - |
dc.contributor.googleauthor | Sun Hwa Lee | - |
dc.contributor.googleauthor | Yoon Hee Choi | - |
dc.contributor.googleauthor | Soo Hyun Kim | - |
dc.contributor.googleauthor | Jin Hong Min | - |
dc.contributor.googleauthor | Su Jin Kim | - |
dc.contributor.googleauthor | Yoo Seok Park | - |
dc.identifier.doi | 10.1016/j.resuscitation.2019.03.039 | - |
dc.contributor.localId | A01592 | - |
dc.relation.journalcode | J02620 | - |
dc.identifier.eissn | 1873-1570 | - |
dc.identifier.pmid | 30953628 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0300957219301091 | - |
dc.subject.keyword | Cardiac arrest | - |
dc.subject.keyword | Grey–white matter ratio | - |
dc.subject.keyword | Neurological outcome | - |
dc.subject.keyword | Post-cardiac arrest syndrome | - |
dc.subject.keyword | Prognostic factor | - |
dc.subject.keyword | Targeted temperature management | - |
dc.contributor.alternativeName | Park, Yoo Seok | - |
dc.contributor.affiliatedAuthor | 박유석 | - |
dc.citation.volume | 140 | - |
dc.citation.startPage | 161 | - |
dc.citation.endPage | 169 | - |
dc.identifier.bibliographicCitation | Resuscitation, Vol.140 : 161-169, 2019 | - |
dc.identifier.rimsid | 64133 | - |
dc.type.rims | ART | - |
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