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Effects of Cerebrolysin® in Patients With Minimally Conscious State After Stroke: An Observational Retrospective Clinical Study

DC FieldValueLanguage
dc.contributor.author김덕용-
dc.contributor.author김준엽-
dc.contributor.author김현정-
dc.date.accessioned2019-09-20T07:50:02Z-
dc.date.available2019-09-20T07:50:02Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171075-
dc.description.abstractIntroduction: The neurotrophic drug Cerebrolysin is composed of low-molecular-weight peptides and amino acids and has been shown to have neuroprotective and neuroplastic properties. Cerebrolysin has been reported to promote the recovery of motor functions in central nervous system disorders; however, the effects on the consciousness improvements in post-stroke patients have not yet been studied extensively. Therefore, we aimed to examine the effectiveness of Cerebrolysin on improving the consciousness level of stroke patients with minimally conscious state (MCS). Materials and Methods: In this retrospective study we included ischemic and/or hemorrhagic stroke patients with MCS according to the Coma Recovery Scale-Revised (CRS-R), who were admitted to our hospital between 2014 and 2017. All patients received comprehensive rehabilitation therapy including physical and occupational therapy. We compared patients treated with Cerebrolysin against patients who did not receive Cerebrolysin. Patients were included in the verum group if they received 10 mL of Cerebrolysin IV for at least 20 days. CRS-R scores were assessed at admission and discharge. Results: Of 1,531 patients screened, 75 were included in the study (Cerebrolysin, n = 43; control, n = 32). Baseline characteristics were similar between groups. At discharge, ~2 months after onset of stroke, Cerebrolysin-treated patients improved significantly in the CRS-R (p = 0.010) after adjustment for confounders using linear mixed model (LMM), especially in the Oromotor (p = 0.003) and Arousal subscales (p = 0.038). No safety issues were observed. Conclusion: This retrospective study suggests that Cerebrolysin may improve the level of consciousness in stroke patients with MCS, which should be further investigated in a well-designed, double-blind, placebo-controlled, randomized trial.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFrontiers in Neurology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffects of Cerebrolysin® in Patients With Minimally Conscious State After Stroke: An Observational Retrospective Clinical Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Rehabilitation Medicine (재활의학교실)-
dc.contributor.googleauthorJun Yup Kim-
dc.contributor.googleauthorHyun Jung Kim-
dc.contributor.googleauthorHyo Seon Choi-
dc.contributor.googleauthorSo Young Park-
dc.contributor.googleauthorDeog Young Kim-
dc.identifier.doi10.3389/fneur.2019.00803-
dc.contributor.localIdA00375-
dc.contributor.localIdA05753-
dc.contributor.localIdA05753-
dc.contributor.localIdA05755-
dc.contributor.localIdA05755-
dc.relation.journalcodeJ02996-
dc.identifier.eissn1664-2295-
dc.identifier.pmid31428035-
dc.subject.keywordCerebrolysin-
dc.subject.keywordclinical study-
dc.subject.keywordconsciousness level-
dc.subject.keywordminimally conscious state-
dc.subject.keywordstroke-
dc.contributor.alternativeNameKim, Deog Young-
dc.contributor.affiliatedAuthor김덕용-
dc.contributor.affiliatedAuthor김준엽-
dc.contributor.affiliatedAuthor김준엽-
dc.contributor.affiliatedAuthor김현정-
dc.contributor.affiliatedAuthor김현정-
dc.citation.volume10-
dc.citation.startPage803-
dc.identifier.bibliographicCitationFrontiers in Neurology, Vol.10 : 803, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers

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