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Stem cell passage affects directional migration of stem cells in electrotaxis

DC Field Value Language
dc.contributor.author박종철-
dc.contributor.author이미희-
dc.contributor.author구민아-
dc.contributor.author선경미-
dc.date.accessioned2019-09-20T07:42:17Z-
dc.date.available2019-09-20T07:42:17Z-
dc.date.issued2019-
dc.identifier.issn1873-5061-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171023-
dc.description.abstractStem cells can differentiate into various body tissues and organs and thus are considered as promising tools for cell therapy and tissue engineering. Early passage stem cells have high differentiation ability compared to late passage stem cells. Thus, it is important to use early passage stem cells in cell therapy. Here, we investigated whether cell migration could be used to compare young and senescent cells. We used 'electrotaxis' where cells under electric treatment move towards the anode or cathode. Without an electric stimulus, stem cells moved randomly. However, under a direct electric current, the cells moved with directionality. Under stimulation with a direct electric current, early passage stem cells moved towards the anode; when the cells became senescent with increasing passages, the percentage of cells migrating to the anode decreased. These results suggest that the behavior of stem cells under the influence of a direct electric current is also related to their passage number. Therefore, electrotaxis migration analysis can be used to distinguish between young cell and senescent cells.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfStem Cell Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleStem cell passage affects directional migration of stem cells in electrotaxis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학교실)-
dc.contributor.googleauthorSeung Hee Hong-
dc.contributor.googleauthorMi Hee Lee-
dc.contributor.googleauthorMin-Ah Koo-
dc.contributor.googleauthorGyeung Mi Seon-
dc.contributor.googleauthorYe Jin Park-
dc.contributor.googleauthorDohyun Kim-
dc.contributor.googleauthorJong-Chul Park-
dc.identifier.doi10.1016/j.scr.2019.101475-
dc.contributor.localIdA01662-
dc.contributor.localIdA02777-
dc.relation.journalcodeJ02680-
dc.identifier.eissn1876-7753-
dc.identifier.pmid31176110-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.affiliatedAuthor박종철-
dc.contributor.affiliatedAuthor이미희-
dc.citation.volume38-
dc.citation.startPage101475-
dc.identifier.bibliographicCitationStem Cell Research, Vol.38 : 101475, 2019-
dc.identifier.rimsid64098-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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