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Insulin Resistance Is Associated with Early Gastric Cancer: A Prospective Multicenter Case Control Study

 Hye Jung Kwon  ;  Moo In Park  ;  Seun Ja Park  ;  Won Moon  ;  Sung Eun Kim  ;  Jae Hyun Kim  ;  Youn Jung Choi  ;  Sang Kil Lee 
 Gut and Liver, Vol.13(2) : 154-160, 2019 
Journal Title
 Gut and Liver 
Issue Date
Aged ; Blood Glucose/analysis ; Blood Pressure ; Body Mass Index ; Case-Control Studies ; Cholesterol/blood ; Fasting/blood ; Female ; Humans ; Hyperglycemia/blood* ; Hyperglycemia/complications* ; Hyperglycemia/physiopathology ; Insulin/blood* ; Insulin Resistance* ; Lipids/blood ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Prospective Studies ; Risk Factors ; Stomach Neoplasms/etiology*
Adiponectin ; Cholesterol ; Early gastric cancer ; HOMA-IR ; Hyperglycemia
Background/Aims: Recently, increased body weight has been found to be associated with an increasing risk of several cancers, including gastric cancer. The true pathogenic role of hyperglycemia in the development of gastric cancer remains unclear as hyperglycemia and its associated conditions may work as carcinogenic factors. The goal of this study was to clarify the factors associated with early gastric cancer and evaluate a homeostasis model assessment of the insulin resistance (HOMA-IR) index, fasting glucose, and lipid profile as predictors of early gastric cancer. Methods: A total of 63 patients with early gastric cancer between November 2012 and March 2013 were included. Preoperative serum lipid profile levels and serum fasting glucose were examined prospectively in patients with early gastric cancer. The same number of controls were evaluated and matched to the early gastric cancer group for age and gender. We performed multivariate logistic regression analysis to identify independent risk factors for early gastric cancer. Results: Univariate analysis showed that risk for early gastric cancer was associated with diastolic blood pressure (BP), total cholesterol, fasting glucose, and HOMA-IR. In the multivariate-adjusted model, higher total cholesterol, fasting glucose, body mass index, and diastolic BP were strongly associated with an increased risk of early gastric cancer. Conclusions: Hyperglycemia, a lower high-density lipoprotein cholesterol level, and a low HOMA-IR level appear to be associated with early gastric cancer risk.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
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