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Refractive Outcomes of 4-Year-old Children after Intravitreal Anti-vascular Endothelial Growth Factor versus Laser Photocoagulation for Retinopathy of Prematurity

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dc.contributor.author강현구-
dc.contributor.author한승한-
dc.contributor.author한진우-
dc.date.accessioned2019-09-20T07:39:38Z-
dc.date.available2019-09-20T07:39:38Z-
dc.date.issued2019-
dc.identifier.issn1011-8942-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170999-
dc.description.abstractPURPOSE: To compare long-term refractive outcomes associated with intravitreal anti-vascular endothelial growth factor (VEGF) versus laser photocoagulation treatment for retinopathy of prematurity (ROP). METHODS: A total of 52 eyes from 27 ROP patients treated at two tertiary referral-based hospitals from August 2006 to December 2013 were reviewed. The primary outcome was refractive error measured at the age of 4 years, accounting for within-patient inter-eye correlation. Secondary outcomes included the recurrence rate and treatment complications. RESULTS: The mean age at refraction was 4.7 ± 0.3 years in the laser group (n = 30) and 4.4 ± 0.3 years in the anti-VEGF group (n = 22). No significant differences were noted in gestational age, birthweight, post-menstrual age at treatment, or ROP stage/zone distribution between groups. Mean spherical equivalent was also not significantly different (-1.0 diopters in the laser group and -0.3 diopters in the injection group, p = 0.603). Clustered regression analysis revealed that only gestational age was significantly correlated with mean spherical equivalent (p < 0.001; 95% confidence interval, -0.007 to -0.002). Recurrence was noted in four eyes (13.3%) in the laser group, but this difference was not significant (p = 0.128). There were no major systemic complications reported in either group. CONCLUSIONS: Treatment type, whether laser or anti-VEGF injection, does not appear to influence long-term refractive outcomes in ROP. Concern regarding refractive outcomes should not be the most important factor when selecting ROP treatment modality.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKJO-
dc.relation.isPartOfKorean Journal of Ophthalmology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleRefractive Outcomes of 4-Year-old Children after Intravitreal Anti-vascular Endothelial Growth Factor versus Laser Photocoagulation for Retinopathy of Prematurity-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorHyun Goo Kang-
dc.contributor.googleauthorTae Young Kim-
dc.contributor.googleauthorJinu Han-
dc.contributor.googleauthorSueng-Han Han-
dc.identifier.doi10.3341/kjo.2019.0011-
dc.contributor.localIdA04873-
dc.contributor.localIdA04303-
dc.contributor.localIdA04329-
dc.relation.journalcodeJ02931-
dc.identifier.eissn2092-9382-
dc.identifier.pmid31179659-
dc.subject.keywordIntravitreal injections-
dc.subject.keywordLaser therapy-
dc.subject.keywordRefractive errors-
dc.subject.keywordRetinopathy of prematurity-
dc.subject.keywordVascular endothelial growth factor A-
dc.contributor.alternativeNameKang, Hyun Goo-
dc.contributor.affiliatedAuthor강현구-
dc.contributor.affiliatedAuthor한승한-
dc.contributor.affiliatedAuthor한진우-
dc.citation.volume33-
dc.citation.number3-
dc.citation.startPage272-
dc.citation.endPage278-
dc.identifier.bibliographicCitationKorean Journal of Ophthalmology, Vol.33(3) : 272-278, 2019-
dc.identifier.rimsid64555-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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