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Effect of bisphosphonate on temporomandibular joint in osteopenia-induced rats by botulinum toxin A injection on masticatory muscle: a preliminary study

Authors
 Jae-Young Kim  ;  Dae-Hoon Kim  ;  Hyo-Won Jang  ;  Kwang-Ho Park  ;  Jong-Ki Huh 
Citation
 Maxillofacial Plastic and Reconstructive Surgery, Vol.41(1) : 11, 2019 
Journal Title
 Maxillofacial Plastic and Reconstructive Surgery 
ISSN
 2288-8101 
Issue Date
2019
Keywords
Bisphosphonate ; Botulinum toxin ; Mandibular condyle ; Temporomandibular joint
Abstract
Background: Botulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle. Bisphosphonate suppresses bone resorption and is used to treat osteopenic or osteoporotic condition. This study aimed to evaluate the effect of bisphosphonate administration on prevention of condylar resorption and botulinum toxin A-induced disuse osteopenia in rats. Results: The volume of the condyle and bone volume/tissue volume (BV/TV, %) showed a strong tendency towards statistical significance (p = 0.052 and 0.058). Trabecular thickness (Tb.Th, mm) and trabecular number (Tb.N, 1/mm) were significantly smaller in the Botox group than in the other groups (p < 0.05). The volume of the condyle and BV/TV in the bisphosphonate 100 and bisphosphonate 200 groups showed similar values when compared with the control group. Conclusion: Bisphosphonate administration after botulinum toxin A injection in the masticatory muscles appears to prevent condyle resorption and botulinum toxin-induced disuse osteopenia in rats.
Files in This Item:
T201902567.pdf Download
DOI
10.1186/s40902-019-0193-5
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae-Hoon(김대훈)
Kim, Jae Young(김재영) ORCID logo https://orcid.org/0000-0002-9423-438X
Park, Kwang Ho(박광호) ORCID logo https://orcid.org/0000-0003-1942-2986
Jang, Hyo Won(장효원)
Huh, Jong Ki(허종기) ORCID logo https://orcid.org/0000-0002-7381-3972
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170998
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