Cited 23 times in

Influence of Radiation Dose to Reconstructed Breast Following Mastectomy on Complication in Breast Cancer Patients Undergoing Two-Stage Prosthetic Breast Reconstruction

DC Field Value Language
dc.contributor.author금기창-
dc.contributor.author김용배-
dc.contributor.author노태석-
dc.contributor.author송승용-
dc.contributor.author오주현-
dc.contributor.author유대현-
dc.contributor.author이동원-
dc.contributor.author장지석-
dc.date.accessioned2019-09-20T07:32:09Z-
dc.date.available2019-09-20T07:32:09Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170939-
dc.description.abstractPurpose: This study investigated the association between radiation dose and complication rate in patients who underwent breast reconstruction to understand the role of radiation hypofractionated regimen, boost radiation therapy (RT), and RT techniques. Methods: We retrospectively evaluated 75 patients treated with post-mastectomy adjuvant RT for breast cancer in the setting of two-stage prosthetic breast reconstruction. Near maximum radiation dose (Dmax) in the 2 or 0.03 cc of reconstructed breast or overlying breast skin was obtained from dose-volume histograms. Results: Post-RT complications occurred in 22.7% of patients. Receiver operating characteristic analysis showed that all near Dmax parameters were able to predict complication risk, which retained statistical significance after adjusting other variables (odds ratio 1.12 per Gy, 95% confidence interval 1.02-1.23) with positive dose-response relationship. In multiple linear regression model (R 2 = 0.92), conventional fractionation (β = 11.7) and 16 fractions in 2.66 Gy regimen (β = 3.9) were the major determinants of near Dmax compared with 15 fractions in 2.66 Gy regimen, followed by utilization of boost RT (β = 3.2). The effect of bolus and dose inhomogeneity seemed minor (P > 0.05). The location of hot spot was not close to the high density metal area of the expander, but close to the surrounding areas of partially deflated expander bag. Conclusions: This study is the first to demonstrate a dose-response relationship between risk of complications and near Dmax, where hypofractionated regimen or boost RT can play an important role. Rigorous RT-quality assurance program and modification of dose constraints could be considered as a critically important component for ongoing trials of hypofractionation. Based on our findings, we initiated a multi-center retrospective study (KROG 18-04) and a prospective study (NCT03523078) to validate our findings.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFrontiers in Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleInfluence of Radiation Dose to Reconstructed Breast Following Mastectomy on Complication in Breast Cancer Patients Undergoing Two-Stage Prosthetic Breast Reconstruction-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorSeung Yong Song-
dc.contributor.googleauthorJoo Hyun Oh-
dc.contributor.googleauthorDae Hyun Lew-
dc.contributor.googleauthorTai Suk Roh-
dc.contributor.googleauthorSe Young Kim-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorDong Won Lee-
dc.contributor.googleauthorYong Bae Kim-
dc.identifier.doi10.3389/fonc.2019.00243-
dc.contributor.localIdA00272-
dc.contributor.localIdA00744-
dc.contributor.localIdA01297-
dc.contributor.localIdA02032-
dc.contributor.localIdA05153-
dc.contributor.localIdA02459-
dc.contributor.localIdA02729-
dc.contributor.localIdA04658-
dc.relation.journalcodeJ03512-
dc.identifier.eissn2234-943X-
dc.identifier.pmid31024845-
dc.subject.keywordbreast reconstruction-
dc.subject.keyworddosimetric analysis-
dc.subject.keywordhypofractionated RT-
dc.subject.keywordimplant-
dc.subject.keywordmastectomy-
dc.subject.keywordradiation dose-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.affiliatedAuthor금기창-
dc.contributor.affiliatedAuthor김용배-
dc.contributor.affiliatedAuthor노태석-
dc.contributor.affiliatedAuthor송승용-
dc.contributor.affiliatedAuthor오주현-
dc.contributor.affiliatedAuthor유대현-
dc.contributor.affiliatedAuthor이동원-
dc.contributor.affiliatedAuthor장지석-
dc.citation.volume9-
dc.citation.startPage243-
dc.identifier.bibliographicCitationFrontiers in Oncology, Vol.9 : 243, 2019-
dc.identifier.rimsid64216-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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