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DIFFERENTIAL DIAGNOSIS FOR VITREORETINAL LYMPHOMA WITH VITREORETINAL FINDINGS, IMMUNOGLOBULIN CLONALITY TESTS, AND INTERLEUKIN LEVELS

DC FieldValueLanguage
dc.contributor.author김민-
dc.contributor.author김승우-
dc.contributor.author이성철-
dc.contributor.author이승규-
dc.contributor.author이준원-
dc.date.accessioned2019-09-20T07:29:57Z-
dc.date.available2019-09-20T07:29:57Z-
dc.date.issued2019-
dc.identifier.issn0275-004X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170925-
dc.description.abstractPURPOSE: To analyze vitreoretinal findings, immunoglobulin clonality tests, and interleukin (IL) levels for diagnosing vitreoretinal lymphoma (VRL). METHODS: Forty-three patients who underwent diagnostic vitrectomy for suspected VRL were retrospectively reviewed. Of those patients finally diagnosed with VRL and nonlymphoma, ophthalmic evaluation and cytology results, IL-6 and IL-10 levels, and immunoglobulin heavy chain and immunoglobulin kappa light chain clonality assays were compared. RESULTS: Sub-retinal pigment epithelium infiltration and veil-pattern vitreous opacity were specific vitreoretinal findings in patients with VRL. The area under the receiver operating characteristic curve of the IL-10-to-IL-6 ratio and of IL-10 levels was 0.972 and 0.931, respectively. A combined immunoglobulin heavy chain and immunoglobulin kappa light chain assay showed increased sensitivity, whereas the determined specificity of immunoglobulin kappa light chain, at 94.12%, was much higher than the 78.95% of immunoglobulin heavy chain. Patients with VRL with atypically elevated IL-6 levels showed extensive and severe sub-retinal pigment epithelium infiltration. CONCLUSION: Newly screened immunoglobulin kappa light chain clonality assays may be useful to distinguish VRL from uveitis with high specificity. When sub-retinal pigment epithelium or retinal infiltration is severe and extensive, the IL-10-to-IL-6 ratio may not be typical and should be carefully interpreted.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfRetina- the Journal of Retinal and Vitreous Diseases-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDIFFERENTIAL DIAGNOSIS FOR VITREORETINAL LYMPHOMA WITH VITREORETINAL FINDINGS, IMMUNOGLOBULIN CLONALITY TESTS, AND INTERLEUKIN LEVELS-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorLee, Junwon-
dc.contributor.googleauthorKim, Seung WOO-
dc.contributor.googleauthorKim, Hyesun-
dc.contributor.googleauthorLee, Christopher SEUNGKYU-
dc.contributor.googleauthorKim, Min-
dc.contributor.googleauthorLee, Sung CHUL-
dc.identifier.doi10.1097/IAE.0000000000002127-
dc.contributor.localIdA00455-
dc.contributor.localIdA04901-
dc.contributor.localIdA04901-
dc.contributor.localIdA02873-
dc.contributor.localIdA02873-
dc.contributor.localIdA02913-
dc.contributor.localIdA02913-
dc.contributor.localIdA03179-
dc.contributor.localIdA03179-
dc.relation.journalcodeJ02621-
dc.identifier.eissn1539-2864-
dc.identifier.pmid29474309-
dc.identifier.urlhttps://oce.ovid.com/article/00006982-201906000-00019/HTML-
dc.contributor.alternativeNameKim, Min-
dc.contributor.affiliatedAuthor김민-
dc.contributor.affiliatedAuthor김승우-
dc.contributor.affiliatedAuthor김승우-
dc.contributor.affiliatedAuthor이성철-
dc.contributor.affiliatedAuthor이성철-
dc.contributor.affiliatedAuthor이승규-
dc.contributor.affiliatedAuthor이승규-
dc.contributor.affiliatedAuthor이준원-
dc.contributor.affiliatedAuthor이준원-
dc.citation.volume39-
dc.citation.number6-
dc.citation.startPage1165-
dc.citation.endPage1176-
dc.identifier.bibliographicCitationRetina- the Journal of Retinal and Vitreous Diseases, Vol.39(6) : 1165-1176, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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