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Safety and tolerability of Korean Red Ginseng in healthy adults: a multicenter, double-blind, randomized, placebo-controlled trial

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dc.contributor.author강희철-
dc.date.accessioned2019-09-20T07:25:01Z-
dc.date.available2019-09-20T07:25:01Z-
dc.date.issued2018-
dc.identifier.issn1226-8453-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170881-
dc.description.abstractBackground: Korean Red Ginseng (KRG) has been used in Asia for its various biological effects, but no studies have investigated the safety of its long-term intake. Therefore, the present study evaluated the safety of KRG intake for 24 weeks. Methods: We randomized 1,000 participants in a 1:1 ratio into two groups, which were treated daily with 2 g of KRG or a placebo for 24 weeks. The primary endpoint was all adverse events and adverse drug reactions (ADRs) that occurred after KRG or placebo administration, which were reported at week 4, 12, and 24 after the baseline visit. Results: In total, 192 and 211 participants experienced adverse events in the KRG and placebo groups (39.2% and 42.0%, respectively; p = 0.361), and 59 and 57 KRG- and placebo-treated individuals reported ADRs (12.0% and 11.4%, respectively; p = 0.737). The frequently occurring ADRs were pruritus (2.0%), headache (1.6%), diarrhea (1.4%), and dizziness (1.2%) in the KRG group and pruritus (2.0%), headache (1.8%), dizziness (1.6%), rash (1.4%), and diarrhea (1.2%) in the placebo group. Discontinuation of drug administration due to ADRs was reported in 13 participants, six (1.2%) and seven (1.4%) in the KRG and placebo groups, respectively (p = 0.814). No significant abnormal changes were revealed by anthropometric, laboratory, and vital sign measurements in the KRG group compared with those in the placebo group. Conclusion: The present study confirms the safety and tolerability of daily intake of 2 g of KRG for 24 weeks by healthy adults.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Korean-
dc.publisherKorean Society of Ginseng-
dc.relation.isPartOfJournal of Ginseng Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSafety and tolerability of Korean Red Ginseng in healthy adults: a multicenter, double-blind, randomized, placebo-controlled trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorSang-Wook Song-
dc.contributor.googleauthorHa-Na Kim-
dc.contributor.googleauthorJae-Yong Shim-
dc.contributor.googleauthorByeong-Yeon Yoo-
dc.contributor.googleauthorDae-Hyun Kim-
dc.contributor.googleauthorSang-Hyun Lee-
dc.contributor.googleauthorJoo-Sung Park-
dc.contributor.googleauthorMoon-Jong Kim-
dc.contributor.googleauthorJun-Hyun Yoo-
dc.contributor.googleauthorBeLong Cho-
dc.contributor.googleauthorHee-Cheol Kang-
dc.contributor.googleauthorKwang-Min Kim-
dc.contributor.googleauthorSung-Soo Kim-
dc.contributor.googleauthorKyung-Soo Kim-
dc.identifier.doi10.1016/j.jgr.2018.07.002-
dc.contributor.localIdA00105-
dc.relation.journalcodeJ01424-
dc.identifier.eissn2093-4947-
dc.identifier.pmid30337818-
dc.subject.keywordAdverse drug reaction-
dc.subject.keywordAdverse event-
dc.subject.keywordKorean Red Ginseng-
dc.subject.keywordSafety-
dc.subject.keywordTolerability-
dc.contributor.alternativeNameKang, Hee Cheol-
dc.contributor.affiliatedAuthor강희철-
dc.citation.volume42-
dc.citation.number4-
dc.citation.startPage571-
dc.citation.endPage576-
dc.identifier.bibliographicCitationJournal of Ginseng Research, Vol.42(4) : 571-576, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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