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Early hypopharyngeal cancer treated with different therapeutic approaches: a single-institution cohort analysis

Authors
 Nalee Kim  ;  Jeongshim Lee  ;  Kyung Hwan Kim  ;  Jong Won Park  ;  Chang Geol Lee  ;  Ki Chang Keum 
Citation
 RADIATION ONCOLOGY JOURNAL, Vol.34(4) : 280-289, 2016 
Journal Title
 RADIATION ONCOLOGY JOURNAL 
ISSN
 2234-1900 
Issue Date
2016
Keywords
Hypopharyngeal neoplasms ; Radiotherapy ; Surgery ; Treatment failure
Abstract
PURPOSE: Early hypopharyngeal squamous cell carcinoma (HPSCC) is a rarely diagnosed disease, for which the optimal treatment has not been defined yet. We assessed patterns of failure and outcomes in early HPSCC treated with various therapeutic approaches to identify its optimal treatment. MATERIALS AND METHODS: Thirty-six patients with stage I (n = 10) and II (n = 26) treated between January 1992 and March 2014 were reviewed. Patients received definitive radiotherapy (RT) (R group, n = 10), surgery only (S group, n = 19), or postoperative RT (PORT group, n = 7). All patients in both the R and PORT groups received elective bilateral neck irradiation. In the S group, 7 patients had ipsilateral and 8 had bilateral dissection, while 4 patients had no elective dissection. RESULTS: At a median follow-up of 48 months, the 5-year locoregional control (LRC) rate was 65%. Six patients had local failure, 1 regional failure (RF), 3 combined locoregional failures, and 2 distant failures. There was no difference in 5-year LRC among the R, S, and PORT groups (p = 0.17). The presence with a pyriform sinus apex extension was a prognosticator related to LRC (p = 0.01) in the multivariate analysis. Patients with a bilaterally treated neck showed a trend toward a lower RF rate (p = 0.08). CONCLUSION: This study shows that patients with early stage HPSCC involving the pyriform sinus apex might need a tailored approach to improve LRC. Additionally, our study confirms elective neck treatment might have an efficacious role in regional control.
Files in This Item:
T201606773.pdf Download
DOI
10.3857/roj.2016.01711
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Kim, Nalee(김나리) ORCID logo https://orcid.org/0000-0003-4742-2772
Lee, Jeong Shim(이정심)
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170451
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