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Prognostic potential of the preoperative plasma complement factor B in resected pancreatic cancer: A pilot study

Authors
 Sung Hyun Kim  ;  Min Jung Lee  ;  Ho Kyung Hwang  ;  Sung Hwan Lee  ;  hoguen Kim  ;  Young-Ki Paik  ;  Chang Moo Kang 
Citation
 CANCER BIOMARKERS, Vol.24(3) : 335-342, 2019 
Journal Title
 CANCER BIOMARKERS 
ISSN
 1574-0153 
Issue Date
2019
Keywords
Biomarker ;  complement factor B ;  pancreatic cancer ; prognosis ; survival
Abstract
BACKGROUND: For patients with pancreatic cancer, a preoperative assessment of prognosis is crucial to predict cancer recurrence and to prepare a postoperative adjuvant strategy and appropriate patient-counsel. OBJECTIVE: We evaluated the prognostic predictive power of complement factor B (CFB) by comparing it to that of other known tumor markers in resected pancreatic cancer patients. METHODS: From 2012 to 2013 period, we retrospectively reviewed the plasma CFB levels of 35 pancreatic cancer patients. The patients were divided into two groups according to serologic CFB values. Disease-free survival (DFS) and overall survival (OS) rates were analyzed. RESULTS: Based on the cut-off values of plasma CFB, 15 patients were placed in the low CFB group and the other 20 patients were placed in the high CFB group. There was a significant difference in DFS between the two groups (Low CFB vs. High CFB: 36.9 months vs. 13.9 months, p: 0.007). In the OS analysis, there was also a significant difference in the survival rates of the two groups (Low CFB vs. High CFB: 49.7 months vs. 29.0 months, p: 0.048). CONCLUSION: Preoperative plasma CFB can be used to predict the prognosis of resectable pancreatic cancers; it outperforms both CA 19-9 and CEA.
Full Text
https://content.iospress.com/articles/cancer-biomarkers/cbm181847
DOI
10.3233/CBM-181847
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Kim, Sung Hyun(김성현)
Kim, Hogeun(김호근)
Hwang, Ho Kyoung(황호경) ORCID logo https://orcid.org/0000-0003-4064-7776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170433
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